A synthetic tripeptide with geroprotective effects in vitro
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H-Ala-Glu-Asp-OH

Item No. 45082

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-alanyl-L-α-glutamyl-L-aspartic acid
CAS Number
85806-95-7
Synonyms
  • AED
  • T-31
Molecular Formula
C12H19N3O8
Formula Weight
333.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
H-AED-OH
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlPBS pH 7.2: Soluble: ≥10 mg/ml
SMILES
OC(C[C@@H](C(O)=O)NC([C@H](CCC(O)=O)NC([C@@H](N)C)=O)=O)=O
InChi Code
InChI=1S/C12H19N3O8/c1-5(13)10(20)14-6(2-3-8(16)17)11(21)15-7(12(22)23)4-9(18)19/h5-7H,2-4,13H2,1H3,(H,14,20)(H,15,21)(H,16,17)(H,18,19)(H,22,23)/t5-,6-,7-/m0/s1
InChi Key
KXEVYGKATAMXJJ-ACZMJKKPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $25

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    5 mg

    $113

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    10 mg

    $200

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    25 mg

    $438

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    Product Description

    H-Ala-Glu-Asp-OH (AED) is a synthetic tripeptide with geroprotective effects in vitro.1,2 It increases proliferation and reduces apoptosis in young and aged rat skin fibroblast cultures but reduces matrix metalloproteinase-9 (MMP-9) levels only in young cultures.1 AED (20 ng/ml) increases sirtuin 1 (SIRT1), SIRT6, and collagen I levels in young and aged human skin fibroblast cultures.2 It also prevents mortality in a mouse model of cisplatin-induced acute kidney injury (AKI) when administered at a dose of 3 µg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lin'kova, N.S., Drobintseva, A.O., Orlova, O.A., et al. Peptide regulation of skin fibroblast functions during their aging in vitro. Bull. Exp. Biol. Med. 161(1), 175-178 (2016).

    2. Fridman, N.V., Linkova, N.S., Kozhevnikova, E.O., et al. Comparison of the effects of KE and AED peptides on functional activity of human skin fibroblasts during their replicative aging. Bull. Exp. Biol. Med. 170(1), 154-157 (2020).

    3. Shchudrova, T.S., Zamorskii, I.I., and Korotun, O.P. Evaluation of a renoprotective potential of organospecific peptides under the conditions of acute kidney injury of different etiology. J. Sport Health Sci. 8(1), 221-227 (2018).