An endogenous peptide
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Histatin 1 (trifluoroacetate salt)

Item No. 45085

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-aspartyl-O-phosphono-L-seryl-L-histidyl-L-αglutamyl-L-lysyl-L-arginyl-L-histidyl-L-histidylglycyl-L-tyrosyl-Larginyl-L-arginyl-L-lysyl-L-phenylalanyl-L-histidyl-L-α-glutamyl-Llysyl-L-histidyl-L-histidyl-L-seryl-L-histidyl-L-arginyl-L-α-glutamyl-Lphenylalanyl-L-prolyl-L-phenylalanyl-L-tyrosylglycyl-L-α-aspartyl-Ltyrosylglycyl-L-seryl-L-asparaginyl-L-tyrosyl-L-leucyl-L-tyrosyl-L-αaspartyl-L-asparagine
Synonyms
  • Hst-1
Molecular Formula
C217H298N69O64P • XCF3COOH
Formula Weight
4928.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
H-D-pS-HEKRHHGYRRKFHEKHHSHREFPFYGDYGSNYLYDN-OH;
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): Soluble: ≥10 mg/ml
SMILES
OC(CC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N)CC(O)=O)=O)COP(O)(O)=O)=O)CC1=CNC=N1)=O)CCC(O)=O)=O)CCCCN)=O)CCCNC(N)=N)=O)CC2=CNC=N2)=O)CC3=CNC=N3)=O)=O)CC4=CC=C(C=C4)O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCCN)=O)CC5=CC=CC=C5)=O)CC6=CNC=N6)=O)CCC(O)=O)=O)CCCCN)=O)CC7=CNC=N7)=O)CC8=CNC=N8)=O)CO)=O)CC9=CNC=N9)=O)CCCNC(N)=N)=O)C(N[C@@H](CC%10=CC=CC=C%10)C(N%11[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CC%12=CC=C(O)C=C%12)C(NCC(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CC%13=CC=C(O)C=C%13)C(N[C@H](C(N[C@@H](CC%14=CC=C(O)C=C%14)C(N[C@H](C(N[C@H](C(O)=O)CC(N)=O)=O)CC(O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)CC%15=CC=C(O)C=C%15)=O)CC%16=CC=CC=C%16)=O)CCC%11)=O)=O)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C217H298N69O64P.C2HF3O2/c1-112(2)71-144(193(325)270-150(78-120-45-55-132(293)56-46-120)197(329)280-161(91-178(309)310)207(339)283-163(213(345)346)89-169(223)295)266-195(327)149(77-119-43-53-131(292)54-44-119)271-205(337)159(88-168(222)294)279-208(340)164(102-287)255-172(298)101-244-181(313)146(75-117-39-49-129(290)50-40-117)268-206(338)160(90-177(307)308)254-171(297)100-243-180(312)145(74-116-37-47-128(289)48-38-116)267-198(330)151(73-114-25-8-4-9-26-114)281-211(343)167-36-22-70-286(167)212(344)162(79-115-27-10-5-11-28-115)282-192(324)143(59-62-175(303)304)263-186(318)139(34-20-68-241-216(228)229)262-199(331)154(82-123-94-234-107-248-123)277-209(341)165(103-288)284-204(336)158(86-127-98-238-111-252-127)276-203(335)157(85-126-97-237-110-251-126)273-188(320)136(31-14-17-65-220)258-191(323)142(58-61-174(301)302)264-200(332)153(81-122-93-233-106-247-122)275-196(328)148(72-113-23-6-3-7-24-113)269-187(319)135(30-13-16-64-219)256-184(316)137(32-18-66-239-214(224)225)259-185(317)138(33-19-67-240-215(226)227)261-194(326)147(76-118-41-51-130(291)52-42-118)253-170(296)99-245-182(314)152(80-121-92-232-105-246-121)272-202(334)156(84-125-96-236-109-250-125)274-189(321)140(35-21-69-242-217(230)231)260-183(315)134(29-12-15-63-218)257-190(322)141(57-60-173(299)300)265-201(333)155(83-124-95-235-108-249-124)278-210(342)166(104-350-351(347,348)349)285-179(311)133(221)87-176(305)306;3-2(4,5)1(6)7/h3-11,23-28,37-56,92-98,105-112,133-167,287-293H,12-22,29-36,57-91,99-104,218-221H2,1-2H3,(H2,222,294)(H2,223,295)(H,232,246)(H,233,247)(H,234,248)(H,235,249)(H,236,250)(H,237,251)(H,238,252)(H,243,312)(H,244,313)(H,245,314)(H,253,296)(H,254,297)(H,255,298)(H,256,316)(H,257,322)(H,258,323)(H,259,317)(H,260,315)(H,261,326)(H,262,331)(H,263,318)(H,264,332)(H,265,333)(H,266,327)(H,267,330)(H,268,338)(H,269,319)(H,270,325)(H,271,337)(H,272,334)(H,273,320)(H,274,321)(H,275,328)(H,276,335)(H,277,341)(H,278,342)(H,279,340)(H,280,329)(H,281,343)(H,282,324)(H,283,339)(H,284,336)(H,285,311)(H,29
InChi Key
JKWRRSAZNHAAAG-YYBHDWETSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Histatin 1 is an endogenous peptide secreted by the salivary glands.1,2 It accelerates wound closure in a scratch assay using TR146 epithelial-like cells and increases adhesion, migration, and the formation of vascular networks in human umbilical vein endothelial cells (HUVECs) and EA.hy926 endothelial cells. Histatin 1 increases angiogenesis in a chick chorioallantoic membrane (CAM) assay.2 It is active against C. albicans (LC50 = 6 µM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Oudhoff, M.J., Bolscher, J.G., Nazmi, K., et al. Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay. The FASEB Journal 22(11), 3805-3812 (2008).

    2. Torres, P., Díaz, J., Arce, M., et al. The salivary peptide histatin-1 promotes endothelial cell adhesion, migration, and angiogenesis. The FASEB Journal 31(11), 4946-4958 (2017).