An inducer of mitophagy
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STOCK1N-57534

Item No. 45107

Product Insert (PDF)
Technical Information
Formal Name
(1′R,3′S,3′aS,6′aR)-5′-[4-(acetyloxy)phenyl]-6-chloro-3′a,6′a-dihydro-7-methyl-3′-(phenylmethyl)-spiro[3H-indole-3,1′(2′H)-pyrrolo[3,4-c]pyrrole]-2,4′,6′(1H,3′H,5′H)-trione
Molecular Formula
C29H24ClN3O5
Formula Weight
530.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(N(C1=CC=C(OC(C)=O)C=C1)C2=O)[C@H]3[C@@H]2[C@]4(C5=C(C(C)=C(Cl)C=C5)NC4=O)N[C@H]3CC6=CC=CC=C6
InChi Code
InChI=1S/C29H24ClN3O5/c1-15-21(30)13-12-20-25(15)31-28(37)29(20)24-23(22(32-29)14-17-6-4-3-5-7-17)26(35)33(27(24)36)18-8-10-19(11-9-18)38-16(2)34/h3-13,22-24,32H,14H2,1-2H3,(H,31,37)/t22-,23+,24-,29-/m0/s1
InChi Key
PLVYGCLVPQZIFZ-MVPDCNEZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $75

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    10 mg

    $120

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    25 mg

    $244

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    Product Description

    STOCK1N-57534 is an inducer of mitophagy, a selective form of autophagy for the clearance of damaged mitochondria.1 It induces the formation of autophagy receptor p62 disulfide-linked conjugates and restores autophagic flux and the formation of p62- and LC3-II-positive autophagosomes in autophagy-related protein 5 knockout (Atg5-/-) mouse embryonic fibroblasts (MEFs) at a concentration of 30 µM. STOCK1N-57534 restores mitophagy in irradiated human diploid fibroblasts (HDFs) and HDFs from aged donors, both expressing the mitophagy reporter mt-mKeima.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kelly, G., Kataura, T., Panek, J., et al. Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule. Dev. Cell 59(15), 1924-1939.e1927 (2024).