A Certified Reference Material of glycodeoxycholic acid
Features
  • This product is qualified as a Certified Reference Material (CRM) that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
Related Products
Labeled Version(s)
31310Glycodeoxycholic Acid-d4
Research Tool(s)
20274Glycodeoxycholic Acid (hydrate)
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Glycodeoxycholic Acid (CRM)

Item No. 45113

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl]-glycine
CAS Number
360-65-6
Synonyms
  • GDCA
Molecular Formula
C26H43NO5
Formula Weight
449.6
Formulation (Request formulation change)
A 1 mg/ml solution in methanol
SMILES
C[C@H](CCC(NCC(O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@@]21C
InChi Code
InChI=1S/C26H43NO5/c1-15(4-9-23(30)27-14-24(31)32)19-7-8-20-18-6-5-16-12-17(28)10-11-25(16,2)21(18)13-22(29)26(19,20)3/h15-22,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/t15-,16-,17-,18+,19-,20+,21+,22+,25+,26-/m1/s1
InChi Key
WVULKSPCQVQLCU-BUXLTGKBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $79

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    Product Description

    Glycodeoxycholic acid (CRM) (Item No. 45113) is a certified reference material categorized as a bile acid conjugate.1 It is a glycine-conjugated form of the secondary bile acid deoxycholic acid (Item Nos. 18231 | 20756). Glycodeoxycholic acid serum levels are increased in cystic fibrosis patients with non-cirrhotic liver disease compared to cystic fibrosis patients without non-cirrhotic liver disease.2 Serum levels of glycodeoxycholic acid are elevated in non-surviving patients with acetaminophen-induced acute liver failure (AALF) compared with survivors.3 Glycodeoxycholic acid levels are also increased in the plasma of patients with asthma.4 This product is intended for use in analytical research applications. This product is also available as a general research tool (Item No. 20274).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lefebvre, P., Cariou, B., Lien, F., et al. Role of bile acids and bile acid receptors in metabolic regulation. Physiol. Rev. 89(1), 147-191 (2009).

    2. Drzymała-Czyż, S., Dziedzic, K., Szwengiel, A., et al. Serum bile acids in cystic fibrosis patients - glycodeoxycholic acid as a potential marker of liver disease. Dig. Liver Dis. 54(1), 111-117 (2022).

    3. Woolbright, B.L., McGill, M.R., Staggs, V.S., et al. Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients. Toxicol. Sci. 142(2), 436-444 (2014).

    4. Comhair, S.A.A., McDunn, J., Bennett, C., et al. Metabolomic endotype of asthma. J. Immunol. 195(2), 643-650 (2015).