An activator of HDAC8
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

TM-2-51

Item No. 45129

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(phenylamino)thioxomethyl]-benzamide
CAS Number
4921-82-8
Synonyms
  • NSC 5817
Molecular Formula
C14H12N2OS
Formula Weight
256.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
S=C(NC(C1=CC=CC=C1)=O)NC2=CC=CC=C2
InChi Code
InChI=1S/C14H12N2OS/c17-13(11-7-3-1-4-8-11)16-14(18)15-12-9-5-2-6-10-12/h1-10H,(H2,15,16,17,18)
InChi Key
GVHZQIIMGRLFMX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 g

    $99

    Add

    5 g

    $297

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    TM-2-51 is an activator of histone deacetylase 8 (HDAC8).1,2 It inhibits the growth of SH-SY5Y neuroblastoma cells expressing wild-type p53 when used at concentrations of 10, 40, and 80 µM.1 TM-2-51 (80 µM) induces apoptosis in the same cells but not in BE(2)-C neuroblastoma cells expressing mutant p53. TM-2-51 inhibits growth and migration of U2OS and 143B osteosarcoma cells in vitro and inhibits tumor growth in a 143B mouse xenograft model when administered at a dose of 10 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Singh, R.K., Cho, K., Padi, S.K., et al. Mechanism of N-Acylthiourea-mediated activation of human histone deacetylase 8 (HDAC8) at molecular and cellular levels. The Journal of Biological Chemisty 290(10), 6607-6619 (2015).

    2. Singh, R.K., Mandal, T., Balsubramanian, N., et al. Histone deacetylase activators: N-acetylthioureas serve as highly potent and isozyme selective activators for human histone deacetylase-8 on a fluorescent substrate. Bioorg. Med. Chem. Lett. 21(19), 5920-5923 (2011).

    3. Wang, L., Bai, X., Zhang, X., et al. Activation of HDAC8 can suppress the proliferation of osteosarcoma cells via TP53 and STAT3/ERK signaling pathways. Ann. Clin. Lab. Sci. 53(6), 920-930 (2023).