An inhibitor of the menin-MLL1 protein-protein interaction
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Product Type

Biochemicals

Research Area

Cancer

Ziftomenib

Item No. 45139

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-methyl-5-[[4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl] methyl]-1-[(2S)-2-[4-(methylsulfonyl)-1-piperazinyl]propyl]-H-indole-2-carbonitrile
CAS Number
2134675-36-6
Synonyms
  • KO-539
Molecular Formula
C33H42F3N9O2S2
Formula Weight
717.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
FC(F)(F)CC1=CC(C(S1)=NC(NC)=N2)=C2NC3CCN(CC4=CC=C5C(C=C(N5C[C@H](C)N6CCN(CC6)S(=O)(C)=O)C#N)=C4C)CC3
InChi Code
InChI=1S/C33H42F3N9O2S2/c1-21(43-11-13-44(14-12-43)49(4,46)47)19-45-25(18-37)15-27-22(2)23(5-6-29(27)45)20-42-9-7-24(8-10-42)39-30-28-16-26(17-33(34,35)36)48-31(28)41-32(38-3)40-30/h5-6,15-16,21,24H,7-14,17,19-20H2,1-4H3,(H2,38,39,40,41)/t21-/m0/s1
InChi Key
BGGALFIXXQOTPY-NRFANRHFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $325

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    10 mg

    $455

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    25 mg

    $731

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    50 mg

    $1,138

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    Cayman Chemical
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    Product Description

    Ziftomenib is an inhibitor of the protein-protein interaction between menin and mixed-lineage leukemia 1 (MLL1).1 It decreases the viability of OCI-AML-3 and MV4-11 acute myeloid leukemia (AML) cells in a concentration-dependent manner. Ziftomenib selectively reduces the viability of p53R175H-expressing MOLM-13 leukemia cells and TP53-/- MOLM-13 cells over wild-type p53-expressing MOLM-13 cells. Ziftomenib (75 mg/kg) increases survival in a patient-derived xenograft (PDX) mouse model of AML. Formulations containing ziftomenib have been used in the treatment of AML.

    WARNING This product is not for human or veterinary use.