A fluorogenic substrate of HDAC6 and SIRT1
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BATCP

Item No. 45143

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1S)-5-(acetylamino)-1-[[[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]amino]carbonyl]pentyl]-carbamic acid, dimethylethyl ester
CAS Number
787549-23-9
Molecular Formula
C23H28F3N3O6
Formula Weight
499.5
Purity
≥95%
Emission
505 nm
Excitation
400 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
FC(F)(C(C1=CC=C(NC([C@H](CCCCNC(C)=O)NC(OC(C)(C)C)=O)=O)C=C1O2)=CC2=O)F
InChi Code
InChI=1S/C23H28F3N3O6/c1-13(30)27-10-6-5-7-17(29-21(33)35-22(2,3)4)20(32)28-14-8-9-15-16(23(24,25)26)12-19(31)34-18(15)11-14/h8-9,11-12,17H,5-7,10H2,1-4H3,(H,27,30)(H,28,32)(H,29,33)/t17-/m0/s1
InChi Key
NVKNRJCOVHAZDK-KRWDZBQOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    BATCP is a fluorogenic substrate for histone deacetylase 6 (HDAC6) and sirtuin 1 (SIRT1).1 Upon enzymatic cleavage by HDAC6 or SIRT1, 7-amino-4-trifluoromethylcoumarin (AFC) is released and its fluorescence can be used to quantify HDAC6 or SIRT1 activity. AFC displays excitation/emission maxima of 400/505 nm, respectively, but can be excited across a broad range of wavelengths.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Heltweg, B., Dequiedt, F., Marshall, B.L., et al. Subtype selective substrates for histone deacetylases. J. Med. Chem. 47(21), 5235-5243 (2004).