ARMC5 (human, recombinant)

Armadillo repeat-containing protein 5 (ARMC5) is a member of the armadillo (ARM) repeat containing family.¹ It is composed of an N-terminal ARM repeat domain and C-terminal BTB/POZ domain that each act as scaffolds for protein-protein interactions. ARMC5 is ubiquitously expressed, localizes to the cytoplasm, and undergoes alternative splicing.^1,2 It interacts with cullin 3 via the BTB domain to form an E3 ligase complex that ubiquitinates proteins such as sterol regulatory element binding protein (SREBP) and several RNA polymerase II subunits, including DNA-directed RNA polymerase II subunit (RPB1).^3,4,5 ARMC5 is involved in T cell proliferation and differentiation, lung morphogenesis, adrenal cortex and neural tube development, and tumor suppression.^1,4 Mutations in ARMC5 are associated with primary bilateral macronodular adrenal hyperplasia (PBMAH).⁶ Cayman’s ARMC5 (human, recombinant) protein can be used for enzyme activity assays and has a calculated molecular weight of 97.7 kDa.

WARNING This product is not for human or veterinary use.

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