Active • Host: E. coli • AA: 2-298 (full length) • MW: 33 kDa
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BIRC7 (human, recombinant)

Item No. 45173

Product Insert (PDF)
Technical Information
Synonyms
  • Baculoviral IAP Repeat-containing Protein 7
  • Kidney Inhibitor of Apoptosis Protein
  • KIAP
  • Livin
  • Melanoma Inhibitor of Apoptosis Protein
  • ML-IAP
  • RING Finger Protein 50
  • RING-type E3 Ubiquitin Transferase BIRC7
  • RNF50
Purity
≥90%
Endotoxin Testing
<1 EU per μg of the protein
Source
Active recombinant human BIRC7 expressed in E. coli
Amino Acids
2-298 (full length)
MW
33 kDa
Formulation (Request formulation change)
50 mM Tris-HCl pH 7.5, with 1 mM DTT, 200 mM sodium chloride and 20% glycerol
UniProt Accession №
Q96CA5
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    50 µg

    $478

    Add
    Cayman Chemical
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    Product Description

    Baculoviral IAP repeat-containing protein 7 (BIRC7) is an E3 ubiquitin ligase and member of the inhibitor of apoptosis (IAP) protein family with roles in the regulation of apoptotic cell death.1,2,3 It is composed of a single BIR domain and a C-terminal RING domain with E3 ubiquitin ligase activity.1 BIRC7 has low or undetectable expression in differentiated adult tissues but is expressed at high levels in spleen, lymph nodes, developing embryonic tissues, and placenta and exhibits isoform-specific cellular localization. Full-length BIRC7 localizes to the cytoplasm and inhibits apoptosis, while truncated BIRC7 isoforms accumulate in the Golgi and have pro-apoptotic functions. BIRC7 is overexpressed in papillary thyroid carcinoma compared with non-cancerous thyroid tissue and positively correlates with metastasis.2 BIRC7 expression is negatively correlated with event-free survival and overall survival in patients with acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML).3 Cayman’s BIRC7 (human, recombinant) protein can be used for enzyme activity and Western blot (WB) applications and has a calculated molecular weight of 33 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rigato, D.B., Branco, P.C., Silva, C.S.M.R., et al. BIRC7 (baculoviral IAP repeat containing 7). Atlas Genet. Cytogenet. Oncol. Haematol. 24(6), 234-247 (2020).

    2. Liu, K., Yu, Q., Li, H., et al. BIRC7 promotes epithelial-mesenchymal transition and metastasis in papillary thyroid carcinoma through restraining autophagy. Am. J. Cancer Res. 10(1), 78-94 (2020).

    3. El-Mesallamy, H.O., Hegab, H.M., and Kamal, A.M. Expression of inhibitor of apoptosis protein (IAP) livin/BIRC7 in acute leukemia in adults: Correlation with prognostic factors and outcome. Leuk. Res. 35(12), 1616-1622 (2011).