Host: Insect cells • AA: 2-1,104 (full length) • Tag: N-terminal His-Strep • MW: 68.8 kDa
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Product Type

Proteins

Research Area

Cancer
Neuroscience
Behavioral Neuroscience
Anxiety

BTBD11 (human, recombinant)

Item No. 45175

Product Insert (PDF)
Technical Information
Synonyms
  • ABTB3
  • Ankyrin Repeat- and BTB/POZ Domain-containing Protein 3
  • BTB/POZ Domain-containing Protein 11
Purity
≥90% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU/µg of the protein as determined by the LAL method
Source
Recombinant human N-terminal His-Strep II-tagged BTBD11 expressed in insect cells
Amino Acids
2-1,104 (full length)
MW
68.8 kDa
Formulation (Request formulation change)
50 mM Tris-HCl, pH 7.5, with 200 mM sodium chloride, 20% glycerol, and 1 mM DTT
UniProt Accession №
A6QL63
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    10 µg

    $267

    Add

    50 µg

    $734

    Add
    Cayman Chemical
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    Product Description

    BTB/POZ domain-containing protein 11 (BTBD11) is a BTB-domain containing protein.1 It is composed of a disordered region, five ankyrin repeats, a BTB domain, and a PDZ-binding motif (PBM). Btbd11 is expressed in cortical and hippocampal inhibitory interneurons. It binds to postsynaptic density protein 95 (Psd-95) and is involved in regulation of glutamatergic synapses and neuronal circuit function. Knockout of the gene encoding Btbd11, Abtb3, in inhibitory neurons expressing the vesicular inhibitory amino acid transporter (VIAAT), also known as VGAT, increases rearing events in mice and decreases anxiety-like behavior in male mice. A SNP in ABTB3 is associated with risk of human papillomavirus-negative (HPV-negative) oropharyngeal cancer.2 Cayman’s BTBD11 (human, recombinant) protein has a calculated molecular weight of 68.8 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bygrave, A.M., Sengupta, A., Jackert, E.P., et al. Btbd11 supports cell-type-specific synaptic function. Cell Rep. 42(6), 112591 (2023).

    2. Ferreiro-Iglesias, A., McKay, J.D., Brenner, N., et al. Germline determinants of humoral immune response to HPV-16 protect against oropharyngeal cancer. Nat. Commun. 12(1), 5945 (2021).