A synthetic peptide spanning the DNAJ-PKAc fusion junction
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DNAJ-PKAc Fusion Peptide (24-mer) (trifluoroacetate salt)

Item No. 45191

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(S)-N1-((S)-1-(((3S,4S,7S,12S)-12-(2-((5S,8S)-1,8-diamino-11-((diaminomethylene)amino)-6,7-dioxoundecan-5-yl)hydrazineyl)-15-((diaminomethylene)amino)-7-(hydroxyamino)-3-methyl-5,6,10,11-tetraoxopentadecan-4-yl)amino)-1-oxo-3-phenylpropan-2-yl)-N4-((6S,9S,17S,22S,25S,28S,33S,36S,39S,42S,45S,48S,51S,56S,59S,63S)-1,1-diamino-28,45,51-tris(4-aminobutyl)-36-benzyl-17,22,33,56,59,63-hexakis(hydroxyamino)-9-(4-hydroxybenzyl)-39-isobutyl-25-isopropyl-42,48-dimethyl-7,8,11,14,18,19,23,24,27,30,34,35,38,41,44,47,50,53,57,58,61,62-docosaoxo-64-phenyl-2,10,13,26,29,37,40,43,46,49,52-undecaazatetrahexacont-1-en-6-yl)-2-(hydroxyamino)succinamide, trifluoracetate
Synonyms
  • DNAJB1-PRKACA Fusion
  • Hepatocellular Carcinoma 24-mer Fusion
Molecular Formula
C136H211N37O40 • XCF3COOH
Formula Weight
3004.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
RKREIFDRYGEEVKEFLAKAKEDF-OH
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
O=C(N[C@@H](CCCCN[H])C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@@H](CCC(O)=O)C(N[C@@](C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@@H](CC1=CC=C(O[H])C=C1)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN[H])C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)C)=O)=O)C)=O)CC(C)C)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)([H])[C@@H](C)CC)=O)=O)=O)[C@H](CCC/N=C(N[H])/N)N[H].FC(F)(F)C(O)=O
InChi Code
InChI=1S/C136H211N37O40.C2HF3O2/c1-9-74(6)110(173-125(204)93(51-56-106(184)185)162-119(198)87(41-28-62-149-135(144)145)158-117(196)85(39-21-25-59-139)157-113(192)82(141)36-27-61-148-134(142)143)132(211)170-97(66-78-32-15-11-16-33-78)128(207)169-98(69-107(186)187)129(208)159-88(42-29-63-150-136(146)147)120(199)166-95(67-80-43-45-81(174)46-44-80)114(193)151-71-101(175)154-89(47-52-102(176)177)121(200)163-92(50-55-105(182)183)124(203)172-109(73(4)5)131(210)164-86(40-22-26-60-140)118(197)161-90(48-53-103(178)179)122(201)167-96(65-77-30-13-10-14-31-77)127(206)165-94(64-72(2)3)126(205)153-76(8)112(191)155-83(37-19-23-57-137)115(194)152-75(7)111(190)156-84(38-20-24-58-138)116(195)160-91(49-54-104(180)181)123(202)168-99(70-108(188)189)130(209)171-100(133(212)213)68-79-34-17-12-18-35-79;3-2(4,5)1(6)7/h10-18,30-35,43-46,72-76,82-100,109-110,174H,9,19-29,36-42,47-71,137-141H2,1-8H3,(H,151,193)(H,152,194)(H,153,205)(H,154,175)(H,155,191)(H,156,190)(H,157,192)(H,158,196)(H,159,208)(H,160,195)(H,161,197)(H,162,198)(H,163,200)(H,164,210)(H,165,206)(H,166,199)(H,167,201)(H,168,202)(H,169,207)(H,170,211)(H,171,209)(H,172,203)(H,173,204)(H,176,177)(H,178,179)(H,180,181)(H,182,183)(H,184,185)(H,186,187)(H,188,189)(H,212,213)(H4,142,143,148)(H4,144,145,149)(H4,146,147,150);(H,6,7)/t74-,75-,76-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,109-,110-;/m0./s1
InChi Key
XRIYWRFRECYIHM-RQSGCYGRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    25 mg

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    Product Description

    DNAJ-PKAc peptide is a synthetic peptide spanning the junction of the DNAJ-PKAc fusion protein found in fibrolamellar carcinoma (FLC) tumors.1 It contains amino acids 59-70 of DNAJ heat shock protein family member B1 (DNAJB1) and 16-27 of PKAα, which are located in the J domain and catalytic domain, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. O'Neill, A.F., Zeme, E.L., Abou-Alfa, G.K., et al. Clinical guideline for the diagnosis and treatment of fibrolamellar carcinoma. Hepatology (2026).