A class I antiarrhythmic agent
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Moricizine (hydrochloride)

Item No. 45203

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[10-[3-(4-morpholinyl)-1-oxopropyl]-10H-phenothiazin-2-yl]-carbamic acid, ethyl ester, monohydrochloride
CAS Number
29560-58-5
Synonyms
  • EN-313
  • Moracizine
Molecular Formula
C22H25N3O4S • HCl
Formula Weight
464.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(NC1=CC=C2SC3=C(N(C2=C1)C(CCN4CCOCC4)=O)C=CC=C3)OCC.Cl
InChi Code
InChI=1S/C22H25N3O4S.ClH/c1-2-29-22(27)23-16-7-8-20-18(15-16)25(17-5-3-4-6-19(17)30-20)21(26)9-10-24-11-13-28-14-12-24;/h3-8,15H,2,9-14H2,1H3,(H,23,27);1H
InChi Key
GAQAKFHSULJNAK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $55

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    25 mg

    $124

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    50 mg

    $220

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    100 mg

    $358

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    Product Description

    Moricizine is a class I antiarrhythmic agent.1 It induces both tonic and phasic blocks of sodium currents in isolated guinea pig atrial myocytes when used at a concentration of 30 µM and induces a tonic block of sodium currents in isolated guinea pig ventricular myocytes at 1 and 10 µM. Moricizine (1-3 mg/kg) reduces spontaneous arrhythmias occurring 24 hours after ligation of the left anterior descending (LAD) coronary artery in dogs as a model of myocardial infarction.2 It also reduces arrhythmias occurring 2-5 days after LAD coronary ligation in the same model. Formulations containing moricizine have previously been used in the treatment of ventricular arrhythmias.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ahmmed, G.U., Hisatome, I., Kurata, Y., et al. Analysis of moricizine block of sodium current in isolated guinea-pig atrial myocytes. Atrioventricular difference of moricizine block. Vascul. Pharmacol. 38(3), 131-141 (2002).

    2. Danilo, P., Jr., Langan, W.B., Rosen, M.R., et al. Effects of the phenothiazine analog, EN-313, on ventricular arrhythmias in the dog. Eur. J. Pharmacol. 45(2), 127-139 (1977).