An inhibitor of uPA
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uPA Inhibitor

Item No. 45221

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-iodo-benzo[b]thiophene-2-carboximidamide, monohydrochloride
CAS Number
149732-36-5
Synonyms
  • B428
  • Urokinase-type Plasminogen Activator Inhibitor
Molecular Formula
C9H7IN2S • HCl
Formula Weight
338.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly Soluble: 0.1-1 mg/mlDMSO: Slightly Soluble: 0.1-1 mg/ml
SMILES
IC1=CC=CC2=C1C=C(C(N)=N)S2.Cl
InChi Code
InChI=1S/C9H7IN2S.ClH/c10-6-2-1-3-7-5(6)4-8(13-7)9(11)12;/h1-4H,(H3,11,12);1H
InChi Key
LSGFKADNXDPWBF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $74

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    5 mg

    $315

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    Product Description

    uPA inhibitor is an inhibitor of urokinase-type plasminogen activator (uPA; IC50 = 0.32 µM).1 It is selective for uPA over tissue-type plasminogen activator (tPA) and plasmin (IC50s = 107 and 352 µM, respectively). uPA inhibitor is cytotoxic to F3II mouse breast cancer cells (IC50 = 18 µM) and inhibits muscle and adipose tissue invasion in an F3II murine breast cancer model when administered at a dose of 20 mg/kg per day.2 It also decreases ethanol consumption and preference in the two-bottle preference test in mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bridges, A.J., Lee, A., Schwartz, C.E., et al. The synthesis of three 4-substituted benzo[b]thiophene-2-carboxamidines as potent and selective inhibitors of urokinase. Bioorg. Med. Chem. 1(6), 403-410 (1993).

    2. Alonso, D.F., Farías, E.F., Ladeda, V., et al. Effects of synthetic urokinase inhibitors on local invasion and metastasis in a murine mammary tumor model. Breast Cancer Res. Treat. 40(3), 209-223 (1996).

    3. Al Maamari, E., Al Ameri, M., Al Mansouri, S., et al. Inhibition of urokinase plasminogen activator "uPA" activity alters ethanol consumption and conditioned place preference in mice. Drug Des. Devel. Ther. 8, 1391-1403 (2014).