An FTase inhibitor
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FPT Inhibitor I

Item No. 45256

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(E,E)-3-oxo-2-(phosphonomethyl)-3-[(3,7,11-trimethyl-2,6,10-dodecatrienyl)amino]-propanoic acid, trisodium salt
CAS Number
162934-54-5
Molecular Formula
C19H29NO6P • 3Na
Formula Weight
467.4
Purity
≥85%
Formulation (Request formulation change)
A solid
SMILES
C/C(C)=C/CC/C(C)=C/CC/C(C)=C/CNC(C(C([O-])=O)CP([O-])([O-])=O)=O.[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C19H32NO6P.3Na/c1-14(2)7-5-8-15(3)9-6-10-16(4)11-12-20-18(21)17(19(22)23)13-27(24,25)26;;;/h7,9,11,17H,5-6,8,10,12-13H2,1-4H3,(H,20,21)(H,22,23)(H2,24,25,26);;;/q;3*+1/p-3/b15-9+,16-11+;;;
InChi Key
KYVYTOYGHFXFRR-FLZBTYJPSA-K
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $216

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    Product Description

    FPT inhibitor I is a farnesyltransferase (FTase) inhibitor (IC50 = 0.083 µM).1 It is selective for FTase over geranylgeranyltransferase I (GGTase I), geranylgeranyltransferase II (GGTase II), squalene synthetase (SQS), and mevalonate kinase (MK; IC50s = 26, 47, 516, and >200 µM, respectively). FPT inhibitor I decreases FTase-mediated farnesylation of H-Ras in a cell-free assay.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Manne, V., Ricca, C.S., Brown, J.G., et al. Ras farnesylation as a target for novel antitumor agents: Potent and selective farnesyl diphosphate analog inhibitors of farnesyltransferase. Drug Dev. Res. 34(2), 121-137 (1995).