A RARγ agonist
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Trifarotene

Item No. 45281

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3′′-(1,1-dimethylethyl)-4′-(2-hydroxyethoxy)-4′′-(1-pyrrolidinyl)-[1,1′:3′,1′′-terphenyl]-4-carboxylic acid
CAS Number
895542-09-3
Synonyms
  • CD5789
Molecular Formula
C29H33NO4
Formula Weight
459.6
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
O=C(C1=CC=C(C2=CC=C(C(C3=CC(C(C)(C)C)=C(N4CCCC4)C=C3)=C2)OCCO)C=C1)O
InChi Code
InChI=1S/C29H33NO4/c1-29(2,3)25-19-23(10-12-26(25)30-14-4-5-15-30)24-18-22(11-13-27(24)34-17-16-31)20-6-8-21(9-7-20)28(32)33/h6-13,18-19,31H,4-5,14-17H2,1-3H3,(H,32,33)
InChi Key
MFBCDACCJCDGBA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $79

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    50 mg

    $356

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    100 mg

    $514

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    Product Description

    Trifarotene is a retinoic acid receptor γ (RARγ) agonist.1 It is selective for RARγ over RARα and RARβ in reporter assays using HeLa cells expressing chimeric RARγ, RARα, or RARβ receptors (EC50s = 7.7, 498, and 125 nM, respectively) and is inactive at the retinoid X receptor (RXR). Topical application of trifarotene (0.1% w/w) reduces ear edema induced by 12-O-tetradecanoylphorbol-1,3-acetate (TPA; Item No. 10008014) in a mouse model of epidermal inflammation. Formulations containing trifarotene have been used in the treatment of acne vulgaris.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aubert, J., Piwinica, D., Bertino, B., et al. Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor-γ agonist trifarotene. Br. J. Dermatol. 179(2), 442-456 (2018).