A potassium-competitive acid blocker
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Abeprazan

Item No. 45283

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(2,4-difluorophenyl)-1-[(3-fluoro phenyl)sulfonyl]-4-methoxy-N-methyl-1H-pyrrole-3-methanamine
CAS Number
1902954-60-2
Synonyms
  • DWP14012
  • Fexuprazan
Molecular Formula
C19H17F3N2O3S
Formula Weight
410.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=S(C1=CC(F)=CC=C1)(N2C=C(CNC)C(OC)=C2C3=C(F)C=C(F)C=C3)=O
InChi Code
InChI=1S/C19H17F3N2O3S/c1-23-10-12-11-24(28(25,26)15-5-3-4-13(20)8-15)18(19(12)27-2)16-7-6-14(21)9-17(16)22/h3-9,11,23H,10H2,1-2H3
InChi Key
OUNXGNDVWVPCOL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $65

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    5 mg

    $163

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    10 mg

    $228

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    25 mg

    $406

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    Product Description

    Abeprazan is a potassium-competitive acid blocker (P-CAB).1,2 Abeprazan (20 µg/ml) increases trans-epithelial electrical resistance (TEER) and levels of the tight junction proteins occludin and mucin-1 (Muc-1) in a Caco-2 colon cell model of ulcerative colitis (UC) induced by dextran sulfate sodium (DSS; Item No. 23250).1 In vivo, abeprazan (20 mg/kg) reduces ileal levels of TNF-α, IL-6, and IL-1β in a mouse model of small intestinal injury induced by indomethacin (IDM; Item No. 70270).2 Formulations containing abeprazan have been used in the treatment of erosive esophagitis (EE) and gastroesophageal reflux disease (GERD).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jeon, J.-H., Lee, J., Baek, Y.-J., et al. Restoration of intestinal barrier function by fexuprazan, a potassium-competitive acid blocker, in Caco-2 cells and its higher gastrointestinal distribution in rats. Biomed. Pharmacother. 188, 118185 (2025).

    2. Lee, Y., Kim, Y., Park, S., et al. Fexuprazan mitigates NSAID-induced small intestinal injury by restoring intestinal barrier integrity in mice. Biomed. Pharmacother. 190, 118386 (2025).