A synthetic peptide containing a palmitoylation motif
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Product Categories

Product Type

Biochemicals
Peptides

Research Area

Cancer
Cell Cycle
Cell Signaling
GTPases

DC-2 Peptide (trifluoroacetate salt)

Item No. 45287

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4S,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37S,40S,43S)-1-amino-31-(2-amino-2-oxoethyl)-43-(((S)-1-(((S)-1-(((R)-4-((S)-1-(((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)pyrrolidin-2-yl)-1-mercapto-3,4-dioxobutan-2-yl)amino)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl)amino)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl)carbamoyl)-10,22,34,37-tetrakis(4-aminobutyl)-25-benzyl-7,13,19,28-tetrakis(3-guanidinopropyl)-4,16-diisobutyl-40-(2-(methylthio)ethyl)-2,5,8,11,14,17,20,23,26,29,32,35,38,41-tetradecaoxo-3,6,9,12,15,18,21,24,27,30,33,36,39,42-tetradecaazapentatetracontan-45-oic acid, trifluoroacetate salt
Molecular Formula
C115H189N43O23S2 • XCF3COOH
Formula Weight
2606.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
H-GLRLRLRLFRNLLMDHHCPW-NH2
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/mlPBS, pH 7.2: Soluble: ≥10 mg/ml
SMILES
[H]NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(N)=O)CC2=CNC3=C2C=CC=C3)=O)=O)CS)=O)CC4=CN=CN4)=O)CC5=CN=CN5)=O)CC(O)=O)=O)CCSC)=O)=O)=O)=O)=O)CC6=CC=CC=C6)=O)=O)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C115H189N43O23S2.C2HF3O2/c1-63(2)48-81(140-91(160)56-120)103(173)146-75(32-19-42-133-112(123)124)97(167)142-71(28-11-15-38-116)94(164)144-77(34-21-44-135-114(127)128)100(170)151-82(49-64(3)4)104(174)147-76(33-20-43-134-113(125)126)98(168)143-74(31-14-18-41-119)99(169)152-83(50-65-24-7-6-8-25-65)105(175)148-78(35-22-45-136-115(129)130)101(171)155-86(54-90(121)159)108(178)145-73(30-13-17-40-118)95(165)141-72(29-12-16-39-117)96(166)149-79(37-47-183-5)102(172)156-87(55-92(161)162)109(179)154-84(52-67-58-131-61-138-67)106(176)153-85(53-68-59-132-62-139-68)107(177)157-88(60-182)111(181)158-46-23-36-89(158)110(180)150-80(93(122)163)51-66-57-137-70-27-10-9-26-69(66)70;3-2(4,5)1(6)7/h6-10,24-27,57-59,61-64,71-89,137,182H,11-23,28-56,60,116-120H2,1-5H3,(H2,121,159)(H2,122,163)(H,131,138)(H,132,139)(H,140,160)(H,141,165)(H,142,167)(H,143,168)(H,144,164)(H,145,178)(H,146,173)(H,147,174)(H,148,175)(H,149,166)(H,150,180)(H,151,170)(H,152,169)(H,153,176)(H,154,179)(H,155,171)(H,156,172)(H,157,177)(H,161,162)(H4,123,124,133)(H4,125,126,134)(H4,127,128,135)(H4,129,130,136);(H,6,7)/t71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-;/m0./s1
InChi Key
JXGHYOXWOPNQOO-KZROFVJCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $221

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    10 mg

    $392

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    25 mg

    $796

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    Product Description

    DC-2 peptide is a synthetic peptide that contains a DHHC palmitoylation motif.1 It reduces H-Ras cell membrane localization in HeLa cells and increases ERK and Akt phosphorylation in SW480 colorectal cancer cells with high EGFR expression but not in SW620 colorectal cancer cells with low EGFR expression. DC-2 reduces viability of HeLa and MDA-MB-231 breast cancer cells at concentrations ranging from 20 to 100 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stillger, K., Platz-Baudin, E., Friedland, F., et al. First steps toward the design of peptides that influence the intracellular palmitoylation machinery. ChemBiochem 26(10), e202500218 (2025).