A 5-HT1 and 5-HT7 receptor agonist
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5-Carboxamidotryptamine (hydrochloride)

Item No. 45295

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(2-aminoethyl)-1H-indole-5-carboxamide, hydrochloride
CAS Number
467451-77-0
Synonyms
  • 5-CT
Molecular Formula
C11H13N3O • XHCl
Formula Weight
203.2
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
NCCC1=CNC2=C1C=C(C(N)=O)C=C2.Cl
InChi Code
InChI=1S/C11H13N3O.ClH/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10;/h1-2,5-6,14H,3-4,12H2,(H2,13,15);1H
InChi Key
YEMXYQIZSINMDY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $149

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    10 mg

    $283

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    25 mg

    $596

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    50 mg

    $1,118

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    Product Description

    5-Carboxyamidotryptamine is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1 and 5-HT7.1,2,3 It binds to the 5-HT1D receptor in postmortem human cortical tissue (IC50s = 1.82 and 2,041 nM for the high- and low-affinity binding sites, respectively) and the 5-HT7 receptor in HEK293 cells expressing 5-HT7 (Ki = 0.79 nM) in radioligand binding assays.4,3 5-Carboxyamidotryptamine induces hypotension and bradycardia and increases hindlimb vascular conductance in anesthetized rats when administered via injection into the rostral ventrolateral medulla.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hoyer, D., and Schoeffter, P. 5-HT receptors: Subtypes and second messengers. J. Recept. Res. 11(1-4), 197-214 (1991).

    2. Zifa, E., and Fillion, G. 5-Hydroxytryptamine receptors. Pharm. Rev. 44(3), 401-458 (1992).

    3. Wood, M., Chaubey, M., Atkinson, P., et al. Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT7 receptor. Eur. J. Pharm. 396(1), 1-8 (2000).

    4. Beer, M.S., Stanton, J.A., Bevan, Y., et al. An investigation of the 5-HT1D receptor binding affinity of 5-hydroxytryptamine, 5-carboxyamidotryptamine and sumatriptan in the central nervous system of seven species. Eur. J. Pharm. 213(2), 193-197 (1992).

    5. Lovick, T.A. Systemic and regional haemodynamic responses to microinjection of 5-HT agonists in the rostral ventrolateral medulla in the rat. Neurosci. Lett. 107(1-3), 157-161 (1989).