A non-radiolabeled form of 18F-THK5351
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Product Categories

Product Type

Biochemicals

Research Area

Neuroscience
Neurodegenerative Disorders

THK5351

Item No. 45302

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-fluoro-3-[[2-[6-(methylamino)-3-pyridinyl]-6-quinolinyl]oxy]-2S-propanol
CAS Number
1707147-26-9
Molecular Formula
C18H18FN3O2
Formula Weight
327.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
CNC1=NC=C(C=C1)C2=NC(C=CC(OC[C@@H](CF)O)=C3)=C3C=C2
InChi Code
InChI=1S/C18H18FN3O2/c1-20-18-7-3-13(10-21-18)17-5-2-12-8-15(4-6-16(12)22-17)24-11-14(23)9-19/h2-8,10,14,23H,9,11H2,1H3,(H,20,21)/t14-/m1/s1
InChi Key
DLVXFZWSPCOWSN-CQSZACIVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $175

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    5 mg

    $438

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    10 mg

    $613

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    25 mg

    $1,094

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    Product Description

    THK5351 is a non-radiolabeled form of 18F-THK5351, which has been used as a PET tracer for selectively imaging tau in animal models of tauopathies.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Harada, R., Okamura, N., Furumoto, S., et al. 18F-THK5351: A Novel pet radiotracer for imaging neurofibrillary pathology in Alzheimer disease. J. Nucl. Med. 57(2), 208-214 (2016).

    2. Moreno-Gonzalez, I., Edwards, G.A., 3rd, Hasan, O., et al. Longitudinal assessment of tau-associated pathology by 18F-THK5351 pet imaging: A histological, biochemical, and behavioral study. Diagnostics (Basel) 11(10), 1874 (2016).