A dual PARP1/2 and TNKS1/2 inhibitor
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Nesuparib

Item No. 45304

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[4-[(1,2,3,4,5,6-hexahydro-5-oxobenzo[h]-1,6-naphthyridin-8-yl)methyl]-1-piperazinyl]-3-pyridinecarbonitrile
CAS Number
2055357-64-5
Synonyms
  • JPI-547
Molecular Formula
C23H24N6O
Formula Weight
400.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(NC1=C2C=CC(CN3CCN(C4=NC=C(C#N)C=C4)CC3)=C1)C5=C2NCCC5
InChi Code
InChI=1S/C23H24N6O/c24-13-17-4-6-21(26-14-17)29-10-8-28(9-11-29)15-16-3-5-18-20(12-16)27-23(30)19-2-1-7-25-22(18)19/h3-6,12,14,25H,1-2,7-11,15H2,(H,27,30)
InChi Key
GRPXLKXGJAGYSD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $55

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    5 mg

    $261

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    10 mg

    $413

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    25 mg

    $756

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    Cayman Chemical
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    Product Description

    Nesuparib is a dual inhibitor of the poly(ADP-ribose) polymerases PARP1/2 and tankyrases TNKS1/2.1 It reduces the proliferation of Capan-1 pancreatic ductal adenocarcinoma (PDAC) cells with an IC50 value of 0.1895 µM. Nesuparib (0.01-1 µM) selectively inhibits the proliferation of, and induces apoptosis and G2/M phase cell cycle arrest in, HPAF-II and AsPC-1 PDAC cells expressing RNF43 loss-of-function mutations over SNU-410 PDAC cells expressing wild-type RNF43. Nesuparib (50 mg/kg) also reduces tumor growth in a Capan-1 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Oh, K.S., Nam, A.R., Bang, J.H., et al. JPI-547, a dual inhibitor of PARP/Tankyrase, shows antitumor activity against pancreatic cancers with homologous recombination repair deficiency or Wnt-addiction. Int. J. Biol. 21(12), 5460-5475 (2025).