An inhibitor of Kv1.3 and Kv1.4
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UK 78282

Item No. 45311

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine, monohydrochloride
CAS Number
136647-02-4
Molecular Formula
C29H35NO2 • HCl
Formula Weight
466.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
COC(C=C1)=CC=C1CCCN2CCC(CC2)COC(C3=CC=CC=C3)C4=CC=CC=C4.Cl
InChi Code
InChI=1S/C29H35NO2.ClH/c1-31-28-16-14-24(15-17-28)9-8-20-30-21-18-25(19-22-30)23-32-29(26-10-4-2-5-11-26)27-12-6-3-7-13-27;/h2-7,10-17,25,29H,8-9,18-23H2,1H3;1H
InChi Key
ZZSQARULZYQMIG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $169

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    10 mg

    $237

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    25 mg

    $465

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    50 mg

    $845

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    Product Description

    UK 78282 is an inhibitor of voltage-gated potassium channel 1.3 (Kv1.3) and Kv1.4 (IC50s = 0.28 and 0.17 µM, respectively).1 It is selective for Kv1.3 and Kv1.4 over Kv1.1-1.2 and Kv1.5-1.6 (IC50s = 2.9-70 µM), Kv3.1, -3.2, and -3.4 (IC50s = 11-127 µM), Kv4.2 (IC50 = 10 µM), and intermediate conductance calcium-activated potassium channel (KCa3.1/IK; IC50 = >30 µM). UK 78282 inhibits phytohemagglutinin-induced proliferation and IL-2 production in T cells (IC50s = 2 and 2.9 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hanson, D.C., Nguyen, A., Mather, R.J., et al. UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br. J. Pharmacol. 126(8), 1707-1716 (1999).