A DDX9 inhibitor
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DHX9-IN-4

Item No. 45314

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-chloro-5-[(methylsulfonyl)amino]phenyl]-5-methyl-4-[5-[(1-methyl-3-azetidinyl)oxy]-2-pyrimidinyl]-2-thiophenecarboxamide
CAS Number
2973401-45-3
Synonyms
  • DEAD-box Helicase 9-IN-4
  • DEAD-box Helicase 9 Inhibitor 4
  • DHX9 Inhibitor 4
Molecular Formula
C21H22ClN5O4S2
Formula Weight
508.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlMethanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C1=CC(C2=NC=C(C=N2)OC3CN(C3)C)=C(C)S1)NC4=CC(Cl)=CC(NS(=O)(C)=O)=C4
InChi Code
InChI=1S/C21H22ClN5O4S2/c1-12-18(20-23-8-16(9-24-20)31-17-10-27(2)11-17)7-19(32-12)21(28)25-14-4-13(22)5-15(6-14)26-33(3,29)30/h4-9,17,26H,10-11H2,1-3H3,(H,25,28)
InChi Key
REJLULZCWIPZCB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    DHX9-IN-4 is an inhibitor of DEAD-box helicase 9 (DDX9; IC50 = 3 nM).1 It reduces the proliferation of LS411N cancer cells (IC50 = 0.658 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Daniels, M.H., Duncan, K.W., Sparling, B.A., et al. Inhibitors of RNA helicase DHX9 and uses thereof. (2023).