An inhibitor of KCa2.1 and KCa2.2
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ICA

Item No. 45333

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-(2-pyridinyl)-2-thiazolyl]-2-pyridinamine
CAS Number
3374-88-7
Molecular Formula
C13H10N4S
Formula Weight
254.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
C1(C2=CC=CC=N2)=CSC(NC3=CC=CC=N3)=N1
InChi Code
InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)
InChi Key
RYCUBTFYRLAMFA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    5 mg

    $328

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    10 mg

    $518

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    25 mg

    $949

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    Cayman Chemical
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    Product Description

    ICA is an inhibitor of small conductance calcium-activated potassium channel 1 (KCa2.1/SK1) and KCa2.2/SK2(IC50s = 43 and 123 nM, respectively, in HEK293 cells expressing the rat channels).1 It prolongs atrial action potential duration and atrial effective refractory period (AERP) and reduces burst pacing-induced atrial fibrillation in isoprenaline- or carbachol-stimulated isolated rat atrial tissue at a concentration of 10 µM.2 ICA is also active against M. tuberculosis H37Rv (MIC = 0.39 µM).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gentles, R.G., Grant-Young, K., Hu, S., et al. Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels. Bioorg. Med. Chem. Lett. 18(19), 5316-5319 (2008).

    2. Skibsbye, L., Bengaard, A.K., Uldum-Nielsen, A.M., et al. Inhibition of small conductance calcium-activated potassium (SK) channels prevents arrhythmias in rat atria during β-adrenergic and muscarinic receptor activation. Front. Physiol. 9, 510 (2018).

    3. Meissner, A., Boshoff, H.I., Vasan, M., et al. Structure-activity relationships of 2-aminothiazoles effective against Mycobacterium tuberculosis. Bioorg. Med. Chem. 21(21), 6385-6397 (2013).