An inhibitor of DAGLα and DAGLβ
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

A1480LS

Item No. 45340

Product Insert (PDF)
Technical Information
Formal Name
(S)-(2-benzyl-4-(6-(trifluoromethyl)pyrazin-2-yl)piperazin-1-yl)(5-phenyl-2H-indazol-2-yl)methanone
Molecular Formula
C30H25F3N6O
Formula Weight
542.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/ml
SMILES
O=C(N1N=C2C=CC(C3=CC=CC=C3)=CC2=C1)N4CCN(C[C@@H]4CC5=CC=CC=C5)C6=NC(C(F)(F)F)=CN=C6
InChi Code
InChI=1S/C30H25F3N6O/c31-30(32,33)27-17-34-18-28(35-27)37-13-14-38(25(20-37)15-21-7-3-1-4-8-21)29(40)39-19-24-16-23(11-12-26(24)36-39)22-9-5-2-6-10-22/h1-12,16-19,25H,13-15,20H2/t25-/m0/s1
InChi Key
LULPTIBVONZWPH-VWLOTQADSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $83

    Add

    5 mg

    $332

    Add

    10 mg

    $540

    Add

    25 mg

    $1,038

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    A1480LS is a peripherally biased inhibitor of diacylglycerol lipase α (DAGLα) and DAGLβ (IC50s = 6 and 4 nM, respectively, in human brain membrane homogenates).1 It reduces levels of the DAGL-derived endocannabinoid 2-arachidonoyl glycerol (2-AG) in peripheral tissue but not in the brain in mice when administered at 20 mg/kg. A1480LS (20 mg/kg, p.o.) reduces mechanical allodynia in rat models of inflammatory pain and chemotherapy-induced neuropathy without inducing CNS adverse effects in the Irwin primary observation test.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tufail, Y.Z., Guijas, C., Kummer, D.A., et al. Suppression of pain transmission and behavior by inhibition of peripheral diacylglycerol metabolism. Cell Chem. Bio. 33(1), 74-90.e19 (2025).