A CTPS1 inhibitor
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Dencatistat

Item No. 45363

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-[(cyclopropylsulfonyl)amino]-4pyrimidinyl]-N-[5-(6-ethoxy-2-pyrazinyl)-2-pyridinyl]tetrahydro-2H-pyran-4-carboxamide
CAS Number
2377000-84-3
Synonyms
  • STP938
Molecular Formula
C24H27N7O5S
Formula Weight
525.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble:
SMILES
O=C(C1(C2=NC(NS(=O)(C3CC3)=O)=NC=C2)CCOCC1)NC(C=C4)=NC=C4C5=CN=CC(OCC)=N5
InChi Code
InChI=1S/C24H27N7O5S/c1-2-36-21-15-25-14-18(28-21)16-3-6-20(27-13-16)30-22(32)24(8-11-35-12-9-24)19-7-10-26-23(29-19)31-37(33,34)17-4-5-17/h3,6-7,10,13-15,17H,2,4-5,8-9,11-12H2,1H3,(H,26,29,31)(H,27,30,32)
InChi Key
WVCJRTCHVUNXST-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Dencatistat is an inhibitor of CTP synthase 1 (CTPS1; IC50 = 0.0093 µM), the enzyme that catalyzes the rate-limiting step in the conversion of UTP to CTP.1 It is selective for CTPS1 over CTPS2 (IC50 = 12.62 µM). Dencatistat inhibits the proliferation of nine cell lines derived from T cell-based cancers (IC50s = 2-183 nM) and 12 cell lines derived from B cell-based cancers (IC50s = 3-356 nM). It also inhibits the proliferation of JeKo-1 mantle cell lymphoma and DoHH2 B cell lymphoma cells and induces apoptosis in MOLT-4, Jurkat, and DoHH2 cells. Dencatistat (6-50 mg/kg every other day) reduces tumor growth in a JeKo-1 mouse xenograft model.

    WARNING This product is not for human or veterinary use.