A derivative of the ADC linker Val-Cit-PABC
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Product Type

Biochemicals

Mal-PEG1-Val-Cit-PABC-OH

Item No. 45364

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide
CAS Number
2055041-37-5
Molecular Formula
C27H38N6O8
Formula Weight
574.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
O=C(C=CC1=O)N1CCOCCC(N[C@@H](C(C)C)C(N[C@H](C(NC2=CC=C(CO)C=C2)=O)CCCNC(N)=O)=O)=O
InChi Code
InChI=1S/C27H38N6O8/c1-17(2)24(32-21(35)11-14-41-15-13-33-22(36)9-10-23(33)37)26(39)31-20(4-3-12-29-27(28)40)25(38)30-19-7-5-18(16-34)6-8-19/h5-10,17,20,24,34H,3-4,11-16H2,1-2H3,(H,30,38)(H,31,39)(H,32,35)(H3,28,29,40)/t20-,24-/m0/s1
InChi Key
AKUCZXRMOZJSAR-RDPSFJRHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $135

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    50 mg

    $257

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    100 mg

    $378

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    Product Description

    Mal-PEG1-Val-Cit-PABC-OH is a derivative of the drug linker Val-Cit-PABC that contains a maleimide moiety and a one-unit PEG moiety.1 Val-Cit-PABC-containing linkers have been used in the synthesis of antibody-drug conjugates (ADCs) and are cleaved by lysosomal cathepsins at the amide bond linking citrulline with p-aminobenzyl carbamate (PABC).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Balamkundu, S., and Liu, C.-F. Lysosomal-cleavable peptide linkers in antibody–drug conjugates. Biomedicines 11(11), 3080 (2023).