An FPR2 agonist
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

BMS 986235

Item No. 45369

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxo-3-pyrrolidinyl]-N′-phenyl-urea
CAS Number
2253947-47-4
Synonyms
  • LAR-1219
Molecular Formula
C18H17F2N3O3
Formula Weight
361.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(NC1=CC=CC=C1)N[C@H]2[C@H](C3=C(C=C(C=C3F)OC)F)CNC2=O
InChi Code
InChI=1S/C18H17F2N3O3/c1-26-11-7-13(19)15(14(20)8-11)12-9-21-17(24)16(12)23-18(25)22-10-5-3-2-4-6-10/h2-8,12,16H,9H2,1H3,(H,21,24)(H2,22,23,25)/t12-,16-/m0/s1
InChi Key
FJZNNKJZHQFMCK-LRDDRELGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $105

    Add

    10 mg

    $200

    Add

    25 mg

    $394

    Add

    50 mg

    $578

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    BMS 986235 is a formyl peptide receptor 2 (FPR2) agonist.1 It selectively induces calcium mobilization in HEK293 cells overexpressing human FPR2 over FPR1 (EC50s = 0.41 and 2,800 nM, respectively). BMS 986235 inhibits chemotaxis of HL-60 human promyeloblast cells and induces phagocytosis of opsonized zymosan by isolated mouse peritoneal macrophages. In vivo, BMS 986235 inhibits neutrophil infiltration into the lungs in a mouse model of LPS-induced lung inflammation. BMS 986235 reduces left ventricle remodeling, scar length, and heart mass in a mouse model of myocardial infarction when administered at a dose of 0.3 mg/kg on days 4-28 post-occlusion. It also reduces right and left ventricle damage and inflammation in a mouse model of Duchenne muscular dystrophy.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Asahina, Y., Wurtz, N.R., Arakawa, K., et al. Discovery of BMS-986235/LAR-1219: A potent formyl peptide receptor 2 (FPR2) selective agonist for the prevention of heart failure. J. Med. Chem. 63(17), 9003-9019 (2020).

    2. Novak, J.S., Lischin, A., Uapinyoying, P., et al. Failure to resolve inflammation contributes to juvenile onset cardiac damage in a mouse model of Duchenne muscular dystrophy. Cell Death Dis. 16(1), 505 (2025).