A peptide linker molecule
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Mal-PEG1-Val-Cit-PAB-PNP

Item No. 45372

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-1-oxopropyl]-L-valyl-N-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-L-ornithinamide
CAS Number
2249935-92-8
Molecular Formula
C34H41N7O12
Formula Weight
739.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C=CC1=O)N1CCOCCC(N[C@@H](C(C)C)C(N[C@H](C(NC2=CC=C(COC(OC3=CC=C([N+]([O-])=O)C=C3)=O)C=C2)=O)CCCNC(N)=O)=O)=O
InChi Code
InChI=1S/C34H41N7O12/c1-21(2)30(39-27(42)15-18-51-19-17-40-28(43)13-14-29(40)44)32(46)38-26(4-3-16-36-33(35)47)31(45)37-23-7-5-22(6-8-23)20-52-34(48)53-25-11-9-24(10-12-25)41(49)50/h5-14,21,26,30H,3-4,15-20H2,1-2H3,(H,37,45)(H,38,46)(H,39,42)(H3,35,36,47)/t26-,30-/m0/s1
InChi Key
PMJNVFJFQFFZRK-YZNIXAGQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $109

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    10 mg

    $196

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    50 mg

    $600

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    100 mg

    $872

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    Product Description

    Mal-PEG1-Val-Cit-PAB-PNP is a peptide linker molecule that has been used in the synthesis of antibody-drug conjugates (ADCs).1,2 It contains a maleimide group that can be conjugated to an antibody and a p-aminobenzyl (PAB) spacer and p-nitrophenyl leaving group that allow it to be linked to active compounds, such as anticancer agents.3 Mal-PEG1-Val-Cit-PAB-PNP contains a PEG1 spacer that improves aqueous solubility, and the Val-Cit motif is cleavable by cathepsin B for release of the active compound at the target site.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Barnett, L., Bender, S., Cho, C.S., et al. DC-sign antibody conjugates comprising sting agonists. (2020).

    2. Zou, B., and Yeung, B.K.S. Antibody-drug conjugates comprising trabectedin and lurbinectedin derivatives. (2024).

    3. Beck, A., Goetsch, L., Dumontet, C., et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat. Rev. Drug Discov. 16(5), 315-337 (2017).