A β-arrestin-2-biased positive allosteric modulator of the NTS1 receptor
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Alternative(s)
45322SBI-810 (hydrochloride)
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SBI-810

Item No. 45376

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[4-[4-(2-methoxyphenyl)-1-piperidinyl]-2-(1-methylcyclopropyl)-6-quinazolinyl]methylamino]-ethanol
CAS Number
1849603-79-7
Molecular Formula
C27H34N4O2
Formula Weight
446.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
CN(CCO)C1=CC(C(N2CCC(CC2)C3=C(C=CC=C3)OC)=N4)=C(C=C1)N=C4C5(C)CC5
InChi Code
InChI=1S/C27H34N4O2/c1-27(12-13-27)26-28-23-9-8-20(30(2)16-17-32)18-22(23)25(29-26)31-14-10-19(11-15-31)21-6-4-5-7-24(21)33-3/h4-9,18-19,32H,10-17H2,1-3H3
InChi Key
TVMPWGASZCIMMZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $172

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    10 mg

    $270

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    25 mg

    $490

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    Product Description

    SBI-810 is a β-arrestin-2-biased positive allosteric modulator of neurotensin receptor 1 (NTS1).1,2 It increases neurotensin-1-induced β-arrestin-2 recruitment to human NTS1 receptors in HEK293T cells (EC50 = 98 nM).2 SBI-810 (12 mg/kg) increases the paw withdrawal threshold in mouse models of postoperative, neuropathic, and inflammatory pain.1 It reduces morphine-induced conditioned place preference (CPP) in mice without inducing CPP itself when administered at a dose of 30 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Guo, R., Chen, O., Zhou, Y., et al. Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain. Cell 188(16), 4332-4349.e4321 (2025).

    2. Pinkerton, A.B., Peddibhotla, S., Yamamoto, F., et al. Discovery of β-arrestin biased, orally bioavailable, and CNS penetrant neurotensin receptor 1 (NTR1) allosteric modulators. J. Med. Chem. 62(17), 8357-8363 (2019).

    Product Citations

    Guo, R., Chen, O., Zhou, Y., et al. Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain. Cell 188(16), 4332-4349.e4321 (2025).