A Smac mimetic
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Product Categories

Product Type

Biochemicals

Research Area

Cancer
Cell Death
Apoptosis

UC-112

Item No. 45378

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol
CAS Number
383392-66-3
Molecular Formula
C22H24N2O2
Formula Weight
348.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
OC1=C2N=CC=CC2=C(COCC3=CC=CC=C3)C=C1CN4CCCC4
InChi Code
InChI=1S/C22H24N2O2/c25-22-18(14-24-11-4-5-12-24)13-19(20-9-6-10-23-21(20)22)16-26-15-17-7-2-1-3-8-17/h1-3,6-10,13,25H,4-5,11-12,14-16H2
InChi Key
LTGLGIQQZXSLLF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $135

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    10 mg

    $216

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    25 mg

    $473

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    Cayman Chemical
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    Product Description

    UC-112 is a Smac mimetic.1 It reduces the level of survivin and induces apoptosis in A375 melanoma and PC3 prostate cancer cells and inhibits the growth of A375, M14 human melanoma, PC3 and DU145 prostate cancer cells (IC50s = 1.6, 2.5, 0.7, and 3.4 µM, respectively). In vivo, UC-112 (20 and 40 mg/kg) reduces tumor growth and intratumoral levels of survivin in an A375 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, J., and Li, W. Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors. J. Pharmacol. Exp. Ther. 349(3), 319-329 (2014).