An sFRP1 inhibitor
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Alternative(s)
26324WAY-316606 (hydrochloride)
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WAY-316606

Item No. 45425

Product Insert (PDF)
Technical Information
Formal Name
5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluor omethyl)-benzenesulfonamide
CAS Number
915759-45-4
Molecular Formula
C18H19F3N2O4S2
Formula Weight
448.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=S(C1=CC=CC=C1)(C2=CC=C(C(F)(F)F)C(S(NC3CCNCC3)(=O)=O)=C2)=O
InChi Code
InChI=1S/C18H19F3N2O4S2/c19-18(20,21)16-7-6-15(28(24,25)14-4-2-1-3-5-14)12-17(16)29(26,27)23-13-8-10-22-11-9-13/h1-7,12-13,22-23H,8-11H2
InChi Key
ITBGJNVZJBVPLJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $99

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    5 mg

    $198

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    10 mg

    $297

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    25 mg

    $619

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    Product Description

    WAY-316606 is an inhibitor of secreted frizzled-related protein 1 (sFRP1; IC50 = 0.5 μM).1 It increases Wnt signaling in U2OS osteosarcoma cells (EC50 = 0.65 μM). WAY-316606 increases total bone area in a murine calvarial organ culture assay when used at concentrations greater than 0.1 nM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Moore, W.J., Kern, J.C., Bhat, R., et al. Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: Part II. Bioorg. Med. Chem. 18(1), 190-201 (2010).

    2. Bodine, P.V., Stauffer, B., Ponce-de-Leon, H., et al. A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone 44(6), 1063-1068 (2009).