An inhibitor of MAO-A and MAO-B
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Iproniazid

Item No. 45450

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(1-methylethyl)hydrazide, 4-pyridinecarboxylic acid
CAS Number
54-92-2
Molecular Formula
C9H13N3O
Formula Weight
179.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/mlPBS (pH 7.2): Soluble: ≥10 mg/ml
SMILES
O=C(C1=CC=NC=C1)NNC(C)C
InChi Code
InChI=1S/C9H13N3O/c1-7(2)11-12-9(13)8-3-5-10-6-4-8/h3-7,11H,1-2H3,(H,12,13)
InChi Key
NYMGNSNKLVNMIA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    50 mg

    $25

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    100 mg

    $45

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    250 mg

    $106

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    Product Description

    Iproniazid is an inhibitor of monoamine oxidase A (MAO-A) and MAO-B (IC50s = 6.56 and 7.54 µM, respectively).1 It reduces immobility in an open swimming test in rats, indicating antidepressant-like activity, when administered at a dose of 10 mg/kg.2 Iproniazid (300 and 400 mg/kg) induces acute hepatic necrosis in rats.3 Formulations containing iproniazid were previously used in the treatment of depression.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Matos, M.J., Viña, D., Picciau, C., et al. Synthesis and evaluation of 6-methyl-3-phenylcoumarins as potent and selective MAO-B inhibitors. Bioorg. Med. Chem. Lett. 19(17), 5053-5055 (2009).

    2. Sun, M.-K., and Alkon, D.L. Open space swimming test to index antidepressant activity. J. Neurosci. Methods 126(1), 35-40 (2003).

    3. Timbrell, J.A. The role of metabolism in the hepatotoxicity of isoniazid and iproniazid. Drug Metab. Rev. 10(1), 125-147 (1979).