An NSAID
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Proquazone

Item No. 45454

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-methyl-1-(1-methylethyl)-4-phenyl-2(1H)-quinazolinone
CAS Number
22760-18-5
Synonyms
  • RU 43-715
  • Sandoz-43-715
Molecular Formula
C18H18N2O
Formula Weight
278.4
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
CC1=CC(N2C(C)C)=C(C(C3=CC=CC=C3)=NC2=O)C=C1
InChi Code
InChI=1S/C18H18N2O/c1-12(2)20-16-11-13(3)9-10-15(16)17(19-18(20)21)14-7-5-4-6-8-14/h4-12H,1-3H3
InChi Key
JTIGKVIOEQASGT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $100

    Add

    5 mg

    $200

    Add

    10 mg

    $300

    Add

    25 mg

    $625

    Add
    Product Description

    Proquazone is a non-steroidal anti-inflammatory drug (NSAID).1,2 It reduces carrageenan-induced edema in rats (ED50 = 5 mg/kg, p.o.) and bradykinin-induced bronchoconstriction in guinea pigs (ED50 = 0.01 mg/kg, i.v.).1 It also inhibits yeast-induced pyresis in rats.2 Formulations containing proquazone have been used in the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Coombs, R.V., Danna, R.P., Denzer, M., et al. Synthesis and antiinflammatory activity of 1-alkyl-4-aryl-2(1H)-quinazolinones and quinazolinethiones. J. Med. Chem. 16(11), 1237-1245 (1973).

    2. Ott, H. 2 (1H)-quinazolinones as novel non-acidic anti-inflammatory agents. Scand. J. Rheumatol. Suppl. 21, 5-7 (1978).