A prodrug form of the DNA alkylating agent melphalan
Related Products
Active Metabolite(s)
16665Melphalan
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Melflufen (hydrochloride)

Item No. 45461

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[bis(2-chloroethyl)amino]-L-phenylalanyl-4-fluoro-L-phenylalanine, ethyl ester, monohydrochloride
CAS Number
380449-54-7
Synonyms
  • J1
  • Melphalan Flufenamide
Molecular Formula
C24H30Cl2FN3O3 • HCl
Formula Weight
534.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
N[C@@H](CC1=CC=C(N(CCCl)CCCl)C=C1)C(N[C@@H](CC2=CC=C(F)C=C2)C(OCC)=O)=O.Cl
InChi Code
InChI=1S/C24H30Cl2FN3O3.ClH/c1-2-33-24(32)22(16-18-3-7-19(27)8-4-18)29-23(31)21(28)15-17-5-9-20(10-6-17)30(13-11-25)14-12-26;/h3-10,21-22H,2,11-16,28H2,1H3,(H,29,31);1H/t21-,22-;/m0./s1
InChi Key
ZCMWSKHHXLCVHI-VROPFNGYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $85

    Add

    10 mg

    $111

    Add

    25 mg

    $213

    Add

    50 mg

    $383

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Melflufen is a prodrug form of the DNA alkylating agent melphalan (Item No. 16665).1,2 Melflufen induces apoptosis and inhibits growth in MM.1R, RPMI-8226, and melphalan-resistant RPMI-8226/LR5 multiple myeloma cells in a concentration-dependent manner.1 It induces DNA damage and inhibits VEGF-induced migration of MM.1S multiple myeloma cells and angiogenesis in human umbilical vascular endothelial cells (HUVECs). Melflufen reduces proliferation and induces cell cycle arrest at the G2/M phase in KM-H2 and SU-DHL-10 lymphoma cells (IC50s = 0.22 and 0.77 µM, respectively).2 In vivo, Melflufen reduces tumor growth and increases survival in DoHH2 lymphoma and MM.1S mouse xenograft models.1,2 Formulations containing melflufen have been used in the treatment of refractory multiple myeloma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chauhan, D., Ray, A., Viktorsson, K., et al. In vitro and in vivo antitumor activity of a novel alkylating agent, melphalan-flufenamide, against multiple myeloma cells. Clin. Cancer Res. 19(11), 3019-3031 (2013).

    2. Delforoush, M., Strese, S., Wickström, M., et al. In vitro and in vivo activity of melflufen (J1) in lymphoma. BMC Cancer 16, 263 (2016).