An inhibitor of Navs and high-voltage activated sodium channels
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Enecadin

Item No. 45478

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(4-fluorophenyl)-2-methyl-6-[[5-(1-piperidinyl)pentyl]oxy]-pyrimidine
CAS Number
259525-01-4
Synonyms
  • NS-7
Molecular Formula
C21H28FN3O
Formula Weight
357.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
CC1=NC(OCCCCCN2CCCCC2)=CC(C3=CC=C(F)C=C3)=N1
InChi Code
InChI=1S/C21H28FN3O/c1-17-23-20(18-8-10-19(22)11-9-18)16-21(24-17)26-15-7-3-6-14-25-12-4-2-5-13-25/h8-11,16H,2-7,12-15H2,1H3
InChi Key
SZSHJTJCJOWMHM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $165

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    1 mg

    $314

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    5 mg

    $825

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    Product Description

    Enecadin is an inhibitor of voltage-gated sodium channels (Navs) and high-voltage activated calcium channels.1 It selectively inhibits Navs and L-, N-, and T-type calcium channels over voltage-gated potassium channels in NG 108-15 cells (IC50s = 7.8, 4.5, 7.3, 17.2, and 160.5 µM, respectively). In vivo, enecadin (0.125-0.5 mg/kg, i.v.) reduces infarct volume and improves motor incoordination in a rat model of stroke induced by permanent middle cerebral artery occlusion (MCAO).2 It also reduces neuronal necrosis in a rabbit model of spinal cord ischemia when administered at a dose of 1 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Suma, C., Hayashi, S., Ukai, Y., et al. Na+ and high-voltage-activated Ca2+ channel blocking actions of NS-7, a novel neuroprotective agent, in NG108-15 cells. Eur. J. Pharmacol. 336(2-3), 283-290 (1997).

    2. Tamura, M., Aoki, Y., Seto, T., et al. Cerebroprotective action of a Na+/Ca2+ channel blocker NS-7. II. Effect on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of permanent middle cerebral artery occlusion in rats. Brain Res. 890(1), 170-176 (2001).

    3. Shi, E., Kazui, T., Jiang, X., et al. NS-7, a novel Na+/Ca2+ channel blocker, prevents neurologic injury after spinal cord ischemia in rabbits. J. Thorac. Cardiovasc. Surg. 129(2), 364-371 (2005).