An inhibitor of voltage-gated sodium channels
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KC 12291 (hydrochloride)

Item No. 45485

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-dimethoxy-N-methyl-N-[3-[(5-phenyl-1,2, 4-thiadiazol-3-yl)oxy]propyl]-benzeneethanamine, monohydrochloride
CAS Number
181936-98-1
Molecular Formula
C22H27N3O3S • HCl
Formula Weight
450.0
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
COC1=CC(CCN(CCCOC2=NSC(C3=CC=CC=C3)=N2)C)=CC=C1OC.Cl
InChi Code
InChI=1S/C22H27N3O3S.ClH/c1-25(14-12-17-10-11-19(26-2)20(16-17)27-3)13-7-15-28-22-23-21(29-24-22)18-8-5-4-6-9-18;/h4-6,8-11,16H,7,12-15H2,1-3H3;1H
InChi Key
KIJPRQYBNQKUAU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $89

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    10 mg

    $169

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    Product Description

    KC 12291 is an inhibitor of voltage-gated sodium channels.1 It reduces peak sodium currents by approximately 60% in isolated rat ventricular cardiomyocytes when used at a concentration of 1 µM. KC 12291 inhibits veratridine or lysophosphatidylcholine-induced diastolic contracture in isolated guinea pig atria (IC50s = 0.55 and 0.79 µM, respectively). In vivo, KC 12291 (0.16 and 0.63 mg/kg) inhibits ST segment elevation in anesthetized rabbits.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. John, G.W., Létienne, R., Le Grand, B., et al. KC 12291: An atypical sodium channel blocker with myocardial antiischemic properties. Cardiovasc. Drug Rev. 22(1), 17-26 (2004).