A negative allosteric modulator of mGluR2
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MNI137

Item No. 45486

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(8-bromo-2,3-dihydro-2-oxo-1H-1,5-benzodiazepin-4-yl)-2-pyridinecarbonitrile
CAS Number
946619-21-2
Molecular Formula
C15H9BrN4O
Formula Weight
341.2
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
N#CC1=CC(C2=NC(C=CC(Br)=C3)=C3NC(C2)=O)=CC=N1
InChi Code
InChI=1S/C15H9BrN4O/c16-10-1-2-12-14(6-10)20-15(21)7-13(19-12)9-3-4-18-11(5-9)8-17/h1-6H,7H2,(H,20,21)
InChi Key
KMKZCMKOSAKVGY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $89

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    10 mg

    $125

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    25 mg

    $223

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    50 mg

    $312

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    Product Description

    MNI137 is a negative allosteric modulator of metabotropic glutamate receptor 2 (mGluR2).1 It selectively inhibits glutamate-induced calcium mobilization in HEK293 cells expressing human mGluR2 (IC50 = 11.4 nM) over HEK293 cells expressing rat mGluR1, -5, -7, or -8 and those expressing human mGluR4 at 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hemstapat, K., Da Costa, H., Nong, Y., et al. A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. J. Pharmacol. Exp. Ther. 322(1), 254-264 (2007).