An ACAT inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

YIC-C8-434

Item No. 45487

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-3-[3,5-dimethoxy-4-(octyloxy)phenyl]-1-[4-(3,4-dimethylphenyl)-1-piperazinyl]-2-propen-1-one
CAS Number
214265-97-1
Molecular Formula
C31H44N2O4
Formula Weight
508.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
CCCCCCCCOC1=C(C=C(C=C1OC)/C=C/C(N2CCN(C3=CC(C)=C(C=C3)C)CC2)=O)OC
InChi Code
InChI=1S/C31H44N2O4/c1-6-7-8-9-10-11-20-37-31-28(35-4)22-26(23-29(31)36-5)13-15-30(34)33-18-16-32(17-19-33)27-14-12-24(2)25(3)21-27/h12-15,21-23H,6-11,16-20H2,1-5H3/b15-13+
InChi Key
YGEPYVAQKIHLFY-FYWRMAATSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $65

    Add

    5 mg

    $244

    Add

    10 mg

    $390

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    YIC-C8-434 is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT; IC50 = 11 nM in isolated rat hepatic microsomes).1 It reduces plasma cholesterol levels by 79% in rats when administered at a dose of 0.005% in a high-cholesterol diet. Oral administration of YIC-C8-434 (8.3 mg/kg per day) reduces cholesterol absorption by the small intestine by 17% in rats.2 YIC-C8-434 is primarily metabolized by the cytochrome P450 (CYP) isoform CYP3A2, which is expressed at lower levels in the female rat liver, and is selectively toxic to female rats, where it reduces food intake, weight gain, and organ weights.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ohishi, K., Aiyama, R., Hatano, H., et al. Structure-activity relationships of N-(3,5-dimethoxy-4-n-octyloxycinnamoyl)-N'-(3,4-dimethylphenyl)piperazine and analogues as inhibitors of acyl-CoA: cholesterol O-acyltransferase. Chem. Pharm. Bull. (Tokyo) 49(7), 830-839 (2001).

    2. Ohishi, K., Sawada, H., Yoshida, Y., et al. Inhibitory effects of N-(3,5-dimethoxy-4-n-octyloxycinnamoyl)-N'-(3,4-dimethylphenyl)piperazine (YIC-C8-434), an acyl-CoA: Cholesterol O-acyltransferase inhibitor, on cholesterol esterification in the intestine and liver. Biol. Pharm. Bull. 26(8), 1125-1128 (2003).

    3. Kaneko, K., Uchida, K., Kobayashi, T., et al. Sex-dependent toxicity of a novel acyl-CoA:cholesterol acyltransferase inhibitor, YIC-C8-434, in relation to sex-specific forms of cytochrome P450 in rats. Toxicol. Sci. 64(2), 259-268 (2001).