An ionizable cationic lipid
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T Cell Lipid 15

Item No. 45491

Product Insert (PDF)
Technical Information
Formal Name
9-octadecenoic acid (9Z)-1,1′-[2-[[3-(dimethylamino)propyl][1,4-dioxo-4-[(1-propylheptyl)oxy]butyl]amino]-1,3-propanediyl] ester
CAS Number
3024023-96-6
Molecular Formula
C58H108N2O7
Formula Weight
945.5
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
SMILES
CCCCCCCC/C=C\CCCCCCCC(OCC(N(C(CCC(OC(CCC)CCCCCC)=O)=O)CCCN(C)C)COC(CCCCCCC/C=C\CCCCCCCC)=O)=O
InChi Code
InChI=1S/C58H108N2O7/c1-7-11-14-17-19-21-23-25-27-29-31-33-35-37-40-45-56(62)65-51-53(52-66-57(63)46-41-38-36-34-32-30-28-26-24-22-20-18-15-12-8-2)60(50-42-49-59(5)6)55(61)47-48-58(64)67-54(43-10-4)44-39-16-13-9-3/h25-28,53-54H,7-24,29-52H2,1-6H3/b27-25-,28-26-
InChi Key
UCGJTGVATJRWHP-LBXGSASVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    Product Description

    T cell lipid 15 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 LNPs containing T cell lipid 15, encapsulating CD22 chimeric antigen receptor (CAR) mRNA, and conjugated to a CD8-targeting nanobody induce CAR presentation in the CD8+ T cell population in isolated human peripheral blood mononuclear cells (PBMCs). These LNPs decrease tumor growth in a humanized NALM6 leukemia mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lemgart, V.T., Sawyer, A.J., Kuhlman, W., et al. Reprogramming CD22 CAR-T cells in vivo using CD8-targeted mRNA-LNPs to treat hematological malignancies. Mol. Ther. 34(5), 2621-2636 (2026).