A broad-spectrum MMP inhibitor
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MMP Inhibitor III

Item No. 45494

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N4-hydroxy-N1-[1-[(methylamino)carbonyl]-3-phenylpropyl]-2-(2-methylpropyl)-butanediamide
CAS Number
927827-98-3
Synonyms
  • Matrix Metalloproteinase Inhibitor III
Molecular Formula
C19H29N3O4
Formula Weight
363.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(NC(C(NC)=O)CCC1=CC=CC=C1)C(CC(C)C)CC(NO)=O
InChi Code
InChI=1S/C19H29N3O4/c1-13(2)11-15(12-17(23)22-26)18(24)21-16(19(25)20-3)10-9-14-7-5-4-6-8-14/h4-8,13,15-16,26H,9-12H2,1-3H3,(H,20,25)(H,21,24)(H,22,23)
InChi Key
FQRZOEBSTPAQBJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $176

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    5 mg

    $660

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    Product Description

    MMP inhibitor III is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs; IC50s = 4.1, 3.6, 8.2, and 6.4 nM for MMP-1, MMP-2, MMP-12, and MMP-13, respectively).1 It also inhibits MMP-3 with an IC50 value of 134 nM.2 MMP inhibitor III reduces ionomycin-induced shedding of CD146 in human microvascular lung endothelial cells (HMVEC-Ls; IC50 = 134 nM).2 It also reduces endometriosis-like lesion formation in chicken chorioallantoic membranes (CAMs) exposed to human endometrium.3 MMP inhibitor III has commonly been used alone and in combination with other MMP inhibitors to evaluate the contribution of MMPs to various cellular processes.2,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, L., Li, X., Zhang, S., et al. Natural products as a gold mine for selective matrix metalloproteinases inhibitors. Bioorg. Med. Chem. 20(13), 4164-4171 (2012).

    2. Boneberg, E.-M., Illges, H., Legler, D.F., et al. Soluble CD146 is generated by ectodomain shedding of membrane CD146 in a calcium-induced, matrix metalloprotease-dependent process. Microvasc. Res. 78(3), 325-331 (2009).

    3. Nap, A.W., Dunselman, G.A.J., de Goeij, A.F.M., et al. Inhibiting MMP activity prevents the development of endometriosis in the chicken chorioallantoic membrane model. Hum. Reprod. 19(10), 2180-2187 (2004).

    4. Lee, Y.S., Choi, H., Cho, H.-R., et al. Downregulation of NKG2DLs by TGF-β in human lung cancer cells. BMC Immunol. 22(1), 44 (2021).

    5. Covington, M.D., Burghardt, R.C., and Parrish, A.R. Ischemia-induced cleavage of cadherins in NRK cells requires MT1-MMP (MMP-14). Am. J. Physiol. Renal Physiol. 290(1), F43-51 (2006).