An inhibitor of Mal homodimerization and TLR signaling
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TSI-13-57

Item No. 45498

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4′-[3-[4-[2-(1-piperidinyl)ethoxy]phenyl]-1H-pyrazole-1,5-diyl]bis-phenol
CAS Number
2257427-45-3
Molecular Formula
C28H29N3O3
Formula Weight
455.6
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
OC1=CC=C(N2C(C3=CC=C(O)C=C3)=CC(C4=CC=C(OCCN5CCCCC5)C=C4)=N2)C=C1
InChi Code
InChI=1S/C28H29N3O3/c32-24-10-4-22(5-11-24)28-20-27(29-31(28)23-8-12-25(33)13-9-23)21-6-14-26(15-7-21)34-19-18-30-16-2-1-3-17-30/h4-15,20,32-33H,1-3,16-19H2
InChi Key
KSIJIGHGXBEURD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $289

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    5 mg

    $723

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    10 mg

    $1,012

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    Cayman Chemical
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    Product Description

    TSI-13-57 is an inhibitor of MyD88 adapter-like protein (Mal), also known as toll/IL-1 receptor domain-containing adaptor protein (TIRAP), homodimerization and of toll-like receptor (TLR) signaling.1 It inhibits the secretion of TNF-α induced by agonists of TLR9, -7, -2, or -4 in RAW 264.7 macrophages (IC50s = 2.7, 6.03, 7.37, and 6.38 µM, respectively). TSI-13-57 (100 and 200 mg/kg) reduces LPS-induced increases in TNF-α levels in mouse plasma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ippagunta, S.K., Pollock, J.A., Sharma, N., et al. Identification of toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins. Sci. Signal 11(543), eaaq1077 (2018).