A stabilizer of mutant p53
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MB710

Item No. 45499

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(diethylamino)-5-hydroxy-6-iodo-7-(1H-pyrrol-1-yl)-4-benzothiazolecarboxylic acid
CAS Number
2230044-57-0
Molecular Formula
C16H16IN3O3S
Formula Weight
457.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C1=C2N=C(N(CC)CC)SC2=C(N3C=CC=C3)C(I)=C1O)O
InChi Code
InChI=1S/C16H16IN3O3S/c1-3-19(4-2)16-18-11-9(15(22)23)13(21)10(17)12(14(11)24-16)20-7-5-6-8-20/h5-8,21H,3-4H2,1-2H3,(H,22,23)
InChi Key
SEBJATZOIHUGAU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $147

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    10 mg

    $245

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    25 mg

    $490

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    Cayman Chemical
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    Product Description

    MB710 is a stabilizer of mutant p53.1 It increases the thermal stability and inhibits aggregation of the mutant p53Y220C DNA-binding domain (Kd = 4 µM). MB710 selectively inhibits growth of NUGC-3 gastric adenocarcinoma cells expressing p53Y220C over WI38 cells that do not express the p53Y220C mutant (IC50s = 90 and >120 µM, respectively). It also selectively reduces the viability of Huh7 p53Y220C-expressing human epithelial carcinoma cells over Huh7 p53-/- cells at 90 and 120 µM, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baud, M.G.J., Bauer, M.R., Verduci, L., et al. Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines. Eur. J. Med. Chem. 152, 101-114 (2018).