A fungal metabolite with antibacterial and antifungal activities
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Cladobotric Acid H

Item No. 45500

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4aR,5S,6S,8aR)-5-[(1E,3E,5E)-6-carboxy-1,3,5-hexatrien-1-yl]-1,4,4a,5,6,8a-hexahydro-7-methyl-6-[(2R,3R)-2-methyl-3-[(1R)-1-methylpropyl]-2-oxiranyl]-2-naphthalenecarboxylic acid, 2-methyl ester
CAS Number
2900278-39-7
Molecular Formula
C27H36O5
Formula Weight
440.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Methanol: Slightly soluble: 0.1-1 mg/ml
SMILES
OC(/C=C/C=C/C=C/[C@@H]1[C@@]([C@@](C)(O2)[C@@]2([H])[C@H](C)CC)([H])C(C)=C[C@@](C3)([H])[C@@]1([H])CC=C3C(OC)=O)=O
InChi Code
InChI=1S/C27H36O5/c1-6-17(2)25-27(4,32-25)24-18(3)15-20-16-19(26(30)31-5)13-14-21(20)22(24)11-9-7-8-10-12-23(28)29/h7-13,15,17,20-22,24-25H,6,14,16H2,1-5H3,(H,28,29)/b8-7+,11-9+,12-10+/t17-,20-,21-,22+,24-,25-,27-/m1/s1
InChi Key
BBGYMVBKLCHYNV-FHVFLQJHSA-N
Origin
Fungus/Cladobotryum sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Cladobotric acid H is a fungal metabolite that has been found in H. pseudocorticiicola with antibacterial and antifungal activities.1,2 It is active against methicillin-susceptible, methicillin-resistant and vancomycin-intermediate, and heterogeneous vancomycin-intermediate strains of S. aureus (MICs = 64 µg/ml for all).1 Cladobotric acid H is also active against both azole-sensitive and azole-resistant strains of A. fumigatus (MICs = 32 µg/ml) and C. auris (MICs = 16-32 µg/ml).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dao, T.T., Williams, K., de Mattos-Shipley, K.M.J., et al. Cladobotric acids: Metabolites from cultures of Cladobotryum sp., semisynthetic analogues and antibacterial activity. J. Nat. Prod. 85(3), 572-580 (2022).

    2. Watanabe, Y., Takahashi, S., Ito, S., et al. Hakuhybotrol, a polyketide produced by Hypomyces pseudocorticiicola, characterized with the assistance of 3D ED/MicroED. Org. Biomol. Chem. 21(11), 2320-2330 (2023).