A BCAT2 inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

BCAT-IN-2

Item No. 45501

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(4-chloro-2,6-difluorophenyl)methyl]amino]-4,7-dihydro-7-oxo-5-propyl-pyrazolo[1,5-a]pyrimidine-3-carbonitrile
CAS Number
1800024-45-6
Synonyms
  • BCAT2-IN-2
Molecular Formula
C17H14ClF2N5O
Formula Weight
377.8
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
FC1=C(CNC2=NN3C(NC(CCC)=CC3=O)=C2C#N)C(F)=CC(Cl)=C1
InChi Code
InChI=1S/C17H14ClF2N5O/c1-2-3-10-6-15(26)25-17(23-10)11(7-21)16(24-25)22-8-12-13(19)4-9(18)5-14(12)20/h4-6,23H,2-3,8H2,1H3,(H,22,24)
InChi Key
SFUVDTPAOHEGCQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $345

    Add

    10 mg

    $518

    Add

    25 mg

    $1,121

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    BCAT-IN-2 is an inhibitor of mitochondrial branched-chain amino acid transaminase (BCAT2; IC50 = 50 nM in a cell-free assay).1 It increases serum levels of leucine, isoleucine, and valine in mice when administered at doses of 10, 30, or 100 mg/kg five hours prior to an amino acid bolus. BCAT-IN-2 also reduces tumor size and metastasis in a DU145 prostate cancer mouse xenograft model.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bertrand, S.M., Ancellin, N., Beaufils, B., et al. The discovery of in vivo active mitochondrial branched-chain aminotransferase (BCATm) inhibitors by hybridizing fragment and HTS hits. J. Med. Chem. 58(18), 7140-7163 (2015).

    2. Mei, W., Wei, M., Tang, C., et al. BCAT2 binding to PCBP1 regulates the PI3K/AKT signaling pathway to inhibit autophagy-related apoptosis and ferroptosis in prostate cancer. Cell Death Dis. 16(1), 337 (2025).