A dual inhibitor of HDAC6 and Sirt2
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Mz325

Item No. 45518

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-butyl-4-[[3-[[2-[[2-[(4,6-dimethyl-2-pyrimidinyl)thio]acetyl]amino]-5-thiazolyl]methyl]phenoxy]methyl]-N-[[4-[(hydroxyamino)carbonyl]phenyl]methyl]-1H-1,2,3-triazole-1-pentanamide
CAS Number
3032670-12-2
Molecular Formula
C38H45N9O5S2
Formula Weight
772.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/ml
SMILES
CCCCN(CC1=CC=C(C(NO)=O)C=C1)C(CCCCN2C=C(N=N2)COC3=CC=CC(CC4=CN=C(S4)NC(CSC5=NC(C)=CC(C)=N5)=O)=C3)=O
InChi Code
InChI=1S/C38H45N9O5S2/c1-4-5-16-46(22-28-12-14-30(15-13-28)36(50)44-51)35(49)11-6-7-17-47-23-31(43-45-47)24-52-32-10-8-9-29(19-32)20-33-21-39-37(54-33)42-34(48)25-53-38-40-26(2)18-27(3)41-38/h8-10,12-15,18-19,21,23,51H,4-7,11,16-17,20,22,24-25H2,1-3H3,(H,44,50)(H,39,42,48)
InChi Key
VNFKTHQLIBPFNF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $39

    Add

    5 mg

    $176

    Add

    10 mg

    $312

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Mz325 is a dual inhibitor of histone deacetylase 6 (HDAC6) and sirtuin 2 (SIRT2; IC50s = 0.043 and 0.32 µM, respectively, in a cell-free assay).1 Mz325 is a heterobifunctional molecule that contains an HDAC6 inhibitor conjugated to a SIRT2 inhibitor via a triazole linker. It is selective for HDAC6 and SIRT2 over HDAC1, -2, and -3 (IC50s = 2.2, 6, and 2.5 µM, respectively) and SIRT1 and -3 (IC50s = >100 µM for both). Mz325 increases α-tubulin acetylation in PC-3M-luc prostate cancer cells and inhibits growth in HGC-27 gastric cancer, W1 ovarian cancer, MCF-7 breast cancer, and PC-3M-luc cells (EC50s = 12.9, 19.2, 21.1, and 30.1 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sinatra, L., Vogelmann, A., Friedrich, F., et al. Development of first-in-class dual Sirt2/HDAC6 inhibitors as molecular tools for dual inhibition of tubulin deacetylation. J. Med. Chem. 66(21), 14787-14814 (2023).