An inhibitor of NR1/3A and NR1/3B subunit-containing NMDA receptors
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GluN1/3A-IN-2

Item No. 45520

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(2-chlorophenyl)[4-(4-fluorophenyl)-1-piperazinyl]methyl]-2-(2-furanyl)-thiazolo[3,2-b][1,2,4]triazol-6-ol
CAS Number
887220-24-8
Synonyms
  • Compound DD-1
  • GluN1/3A Inhibitor 2
Molecular Formula
C25H21ClFN5O2S
Formula Weight
510.0
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
FC1=CC=C(N2CCN(C(C3=C(Cl)C=CC=C3)C4=C(O)N5N=C(C6=CC=CO6)N=C5S4)CC2)C=C1
InChi Code
InChI=1S/C25H21ClFN5O2S/c26-19-5-2-1-4-18(19)21(31-13-11-30(12-14-31)17-9-7-16(27)8-10-17)22-24(33)32-25(35-22)28-23(29-32)20-6-3-15-34-20/h1-10,15,21,33H,11-14H2
InChi Key
FVBYHOHZZRLYMW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $65

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    5 mg

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    Product Description

    GluN1/3A-IN-2 is an inhibitor of NR1/3A and NR1/3B subunit-containing NMDA receptors (IC50s = 1.56 and 0.12 µM, respectively).1 It is selective for NR1/3A and NR1/3B subunit-containing NMDA receptors over those containing NR1/2A subunits (IC50 = >30 µM). GluN1/3A-IN-2 inhibits glycine-induced currents in a whole-cell patch-clamp assay using HEK293 cells expressing NR1/3A subunit-containing NMDA receptors.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, S.W., Zeng, Y., Wu, S.N., et al. Discovery of selective GluN1/GluN3A NMDA receptor inhibitors using integrated AI and physics-based approaches. Acta. Pharmacol. Sin. 47(1), 22-31 (2026).