A spleen-targeted ionizable cationic lipid
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H5T5

Item No. 45538

Product Insert (PDF)
Technical Information
Formal Name
bis((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl) 3,3'-((3-((3-(dimethylamino)propyl)(3-oxo-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)oxy)propyl)amino)propyl)azanediyl)dipropionate
CAS Number
3097464-85-9
Molecular Formula
C62H105N3O6
Formula Weight
988.5
Purity
≥95%
Formulation (Request formulation change)
A 50 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly soluble: 0.1-1 mg/mlMethyl Acetate: Soluble: ≥10 mg/ml
SMILES
O=C(OC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)CCN(CCC(OC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)=O)CCCN(CCC(OC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)=O)CCCN(C)C
InChi Code
InChI=1S/C62H105N3O6/c1-51(2)23-15-26-54(7)29-18-32-57(10)38-48-69-60(66)35-45-64(42-21-41-63(13)14)43-22-44-65(46-36-61(67)70-49-39-58(11)33-19-30-55(8)27-16-24-52(3)4)47-37-62(68)71-50-40-59(12)34-20-31-56(9)28-17-25-53(5)6/h23-25,29-31,38-40H,15-22,26-28,32-37,41-50H2,1-14H3/b54-29+,55-30+,56-31+,57-38+,58-39+,59-40+
InChi Key
KAOTWUOARLTXPD-LPGLGUPKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $85

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    10 mg

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    50 mg

    $595

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    Cayman Chemical
    Ionizable Lipids – Your Path from R&D to GMP

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    Product Description

    H5T5 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 LNPs containing H5T5 primarily target the spleen, but also the bone marrow, in mice after intravenous administration. H5T5-containing LNPs encapsulating anti-HER2 chimeric antigen receptor (CAR) mRNA (H5T5 LNP-CARHER2) generate a diverse population of CAR+ immune cells, including T cells, dendritic cells, and natural killer (NK) cells, in mice. H5T5 LNP-CARHER2 also reduce tumor growth in murine CT26 lung metastasis and B16/F10 melanoma models established using human HER2-expressing cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yin, Q., Liang, X., Zhang, C., et al. Lipid nanoparticle-mediated in vivo generation of panCAR immune cells for solid tumor immunotherapy. Proc. Natl. Acad. Sci. U S A 123(8), e2509698123 (2026).