A telomeric G-quadruplex ligand
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CA11

Item No. 45555

Product Insert (PDF)
Technical Information
Formal Name
3-(diethylamino)-N-[4-[[2-(1-pyrrolidinyl)-4-quinazolinyl]amino]phenyl]-propanamide
CAS Number
3094716-52-3
Molecular Formula
C25H32N6O
Formula Weight
432.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(CCN(CC)CC)NC(C=C1)=CC=C1NC2=NC(N3CCCC3)=NC4=CC=CC=C42
InChi Code
InChI=1S/C25H32N6O/c1-3-30(4-2)18-15-23(32)26-19-11-13-20(14-12-19)27-24-21-9-5-6-10-22(21)28-25(29-24)31-16-7-8-17-31/h5-6,9-14H,3-4,7-8,15-18H2,1-2H3,(H,26,32)(H,27,28,29)
InChi Key
UNCPRPOWSLTXOD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $150

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    5 mg

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    10 mg

    $975

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    Cayman Chemical
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    Product Description

    CA11 is a telomeric guanine-quadruplex (G-quadruplex) ligand.1 It binds to G-quadruplexes (Kd = 5.8 µM), increases the melting temperature of dimeric telomeric G-quadruplexes by 12.1°C at 10 µM, and inhibits Bloom syndrome protein (BLM) and G4 resolvase 1 (G4R1), also known as DEAH-box helicase 36 (DHX36), binding to telomeric G-quadruplex DNA. CA11 inhibits the proliferation of HCT116 colon cancer cells (IC50 = 0.4 µM). It increases the levels of Z-DNA-binding protein 1 (ZBP1), telomeric repeat-containing RNA (TERRA), cyclic GMP-AMP (cGAMP) synthase (cGAS), STING, and LC3B, indicating induction of telomere crisis and autophagy. CA11 (20 and 40 mg/kg) decreases tumor volume and weight and increases intratumoral T cell and M1-polarized macrophage infiltration in an MC-38 murine colon carcinoma model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cai, J.-H., Shi, Y.-H., Yang, D.-Y., et al. An orally available telomeric G‑quadruplex ligand induces telomere crisis and dual DNA/RNA-sensing innate immunity for cancer therapy. J. Med. Chem. 69(6), 6885-6901 (2026).