A GABA receptor agonist
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Progabide

Item No. 45568

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[(4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methylene]amino]-butanamide
CAS Number
62666-20-0
Synonyms
  • SL 76002
Molecular Formula
C17H16ClFN2O2
Formula Weight
334.8
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
OC1=CC=C(C=C1C(C2=CC=C(Cl)C=C2)=NCCCC(N)=O)F
InChi Code
InChI=1S/C17H16ClFN2O2/c18-12-5-3-11(4-6-12)17(21-9-1-2-16(20)23)14-10-13(19)7-8-15(14)22/h3-8,10,22H,1-2,9H2,(H2,20,23)
InChi Key
IBALRBWGSVJPAP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    10 mg

    $45

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    25 mg

    $107

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    50 mg

    $203

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    100 mg

    $383

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    Product Description

    Progabide is a GABA receptor agonist.1 It selectively binds to the GABAA and GABAB receptors in postmortem rat cortical membranes (IC50s = 35 and 100 µM, respectively) over α- and β-adrenergic, dopamine, serotonin, histamine H1, and muscarinic receptors (IC50s = >100 µM) in radioligand binding assays. Progabide (200 mg/kg) increases survival and reduces seizure progression to status epilepticus in rats.2 It suppresses ethanol withdrawal-induced tremors and seizures in rats.3 Formulations containing progabide have been used in the treatment of epilepsy.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lloyd, K.G., Arbilla, S., Beaumont, K., et al. γ-Aminobutyric acid (GABA) receptor stimulation. II. Specificity of progabide (SL 76002) and SL 75102 for the GABA receptor. J. Pharmacol. Exp. Ther. 220(3), 672-677 (1982).

    2. Mecarelli, O., de Feo, M.R., Rina, M.F., et al. Effects of progabide on bicuculline-induced epileptic seizures in developing rats. Clin. Neuropharmacol. 11(5), 443-453 (1988).

    3. Fadda, F., Mosca, E., Meloni, R., et al. Suppression by progabide of ethanol withdrawal syndrome in rats. Eur. J. Pharmacol. 109(3), 321-325 (1985).