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Research Tool(s)
33474SM-102

Product Categories

Product Type

API/GMP

GMP SM-102

API: Manufactured in Accordance with CGMP Guidelines
Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-[(2-hydroxyethyl)[6-oxo-6-(undecyloxy)hexyl]amino]-octanoic acid, 1-octylnonyl ester
CAS Number
2089251-47-6
Synonyms
  • CAY10779
  • Lipid H
  • LNP-102
Molecular Formula
C44H87NO5
Formula Weight
710.2
Appearance
Colorless to yellowish, oily liquid
SMILES
OCCN(CCCCCCCC(OC(CCCCCCCC)CCCCCCCC)=O)CCCCCC(OCCCCCCCCCCC)=O
InChi Code
InChI=1S/C44H87NO5/c1-4-7-10-13-16-17-18-24-32-41-49-43(47)35-29-25-31-38-45(39-40-46)37-30-23-19-22-28-36-44(48)50-42(33-26-20-14-11-8-5-2)34-27-21-15-12-9-6-3/h42,46H,4-41H2,1-3H3
InChi Key
BGNVBNJYBVCBJH-UHFFFAOYSA-N
Product Description

SM-102 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA and plasmid DNA.1,2 SM-102 is manufactured as an excipient suitable for use in LNP preparation and small molecule encapsulation at Cayman Chemical in Ann Arbor, MI. GMP material appropriate for clinical trials is available. (NOTE: This product is subject to licensing for use in commercial applications.)

References & Product Citations
Product Description References

1. Sabnis, S., Kumarasinghe , E.S., Salerno, T., et al. A novel amino lipid series for mRNA delivery: Improved endosomal escape and sustained pharmacology and safety in non-human primates. Mol. Ther. 26(6), 1509-1519 (2018).

2. Zhang, W., Pfeifle, A., Lansdell, C., et al. The expression kinetics and immunogenicity of lipid nanoparticles delivering plasmid DNA and mRNA in mice. Vaccines (Basel) 11(10), 1580 (2023).